Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale

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Fältnamn	Indikatorer	Metadata
000		05015naa a2200745 4500
001		oai:gup.ub.gu.se/308461
003		SwePub
008		240528s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3084612 URI
024	7	a https://doi.org/10.1007/s11136-021-02939-62 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Singer, S.4 aut
245	1 0	a Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale
264		c 2021-07-16
264	1	b Springer Science and Business Media LLC,c 2022
520		a Purpose The aim of this study was to explore what methods should be used to determine the minimal important difference (MID) and minimal important change (MIC) in scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43. Methods In an international multi-centre study, patients with head and neck cancer completed the EORTC QLQ-HN43 before the onset of treatment (t1), three months after baseline (t2), and six months after baseline (t3). The methods explored for determining the MID were: (1) group comparisons based on performance status; (2) 0.5 and 0.3 standard deviation and standard error of the mean. The methods examined for the MIC were patients' subjective change ratings and receiver-operating characteristics (ROC) curves, predictive modelling, standard deviation, and standard error of the mean. The EORTC QLQ-HN43 Swallowing scale was used to investigate these methods. Results From 28 hospitals in 18 countries, 503 patients participated. Correlations with the performance status were \|r\|< 0.4 in 17 out of 19 scales; hence, performance status was regarded as an unsuitable anchor. The ROC approach yielded an implausible MIC and was also discarded. The remaining approaches worked well and delivered MID values ranging from 10 to 14; the MIC for deterioration ranged from 8 to 16 and the MIC for improvement from - 3 to - 14. Conclusions For determining MIDs of the remaining scales of the EORTC QLQ-HN43, we will omit comparisons of groups based on the Karnofsky Performance Score. Other external anchors are needed instead. Distribution-based methods worked well and will be applied as a starting strategy for analyses. For the calculation of MICs, subjective change ratings, predictive modelling, and standard-deviation based approaches are suitable methods whereas ROC analyses seem to be inappropriate.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Minimal important difference
653		a Minimal important change
653		a MCID
653		a Clinical significance
653		a Subjective significance
653		a EORTC QLQ-HN43
700	1	a Hammerlid, Eva,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar,Institute of Clinical Sciences, Department of Otorhinolaryngology4 aut0 (Swepub:gu)xhamev
700	1	a Tomaszewska, I. M.4 aut
700	1	a Amdal, C. D.4 aut
700	1	a Bjordal, K.4 aut
700	1	a Herlofson, B. B.4 aut
700	1	a Santos, M.4 aut
700	1	a Silva, J. C.4 aut
700	1	a Mehanna, H.4 aut
700	1	a Fullerton, A.4 aut
700	1	a Brannan, C.4 aut
700	1	a Gonzalez, L. F.4 aut
700	1	a Inhestern, J.4 aut
700	1	a Pinto, M.4 aut
700	1	a Arraras, J. I.4 aut
700	1	a Yarom, N.4 aut
700	1	a Bonomo, P.4 aut
700	1	a Baumann, I.4 aut
700	1	a Galalae, R.4 aut
700	1	a Nicolatou-Galitis, O.4 aut
700	1	a Kiyota, N.4 aut
700	1	a Raber-Durlacher, J.4 aut
700	1	a Salem, D.4 aut
700	1	a Fabian, A.4 aut
700	1	a Boehm, A.4 aut
700	1	a Krejovic-Trivic, S.4 aut
700	1	a Chie, W. C.4 aut
700	1	a Taylor, K.4 aut
700	1	a Simon, C.4 aut
700	1	a Licitra, L.4 aut
700	1	a Sherman, A. C.4 aut
700	1	a Eortc Quality Life Grp, Eortc Quality Life Grp4 aut
700	1	a Eortc Head Neck Canc Grp, Eortc Head Neck Canc Grp4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar4 org
773	0	t Quality of Life Researchd : Springer Science and Business Media LLCg 31, s. 841-853q 31<841-853x 0962-9343x 1573-2649
856	4	u https://link.springer.com/content/pdf/10.1007/s11136-021-02939-6.pdf
856	4 8	u https://gup.ub.gu.se/publication/308461
856	4 8	u https://doi.org/10.1007/s11136-021-02939-6

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