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Sökning: WFRF:(Holscher A) > (2015-2019) > Surgical management...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003784naa a2200409 4500
001oai:prod.swepub.kib.ki.se:137918005
003SwePub
008240811s2018 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1379180052 URI
0247 a https://doi.org/10.1093/dote/dox1462 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mege, D4 aut
2451 0a Surgical management of esophageal sarcoma: a multicenter European experience
264 c 2018-02-09
264 1b Oxford University Press (OUP),c 2018
520 a Esophageal sarcomas are rare and evidence in literature is scarce making their management difficult. The objective is to report surgical and oncological outcomes of esophageal sarcoma in a large multicenter European cohort. This is a retrospective multicenter study including all patients who underwent en-bloc esophagectomy for esophageal sarcoma in seven European tertiary referral centers between 1987 and 2016. The main outcomes and measures are pathological results, early and long-term outcomes. Among 10,936 esophageal resections for cancer, 21 (0.2%) patients with esophageal sarcoma were identified. The majority of tumors was located in the middle (n = 7) and distal (n = 9) third of the esophagus. Neoadjuvant chemoradiotherapy was performed in five patients. All the patients underwent en-bloc transthoracic esophagectomy (19 open, 2 minimally invasive). Postoperative mortality occurred in 1 patient (5%). One patient received adjuvant chemotherapy. Definitive pathological results were carcinosarcoma (n = 7), leiomyosarcoma (n = 5), and other types of sarcoma (n = 9). Microscopic R1 resection was present in one patient (5%) and seven patients (33%) had positive lymph nodes. Median follow-up was 16 (3–79) months in 20 of 21 patients (95%). One-, 3-, and 5-year overall survival rates were 74%, 43%, and 35%, respectively. One-, 3- and 5-years disease-free survival rates were 58%, 40%, and 33%, respectively. Median overall survival was 6 months in N+ patients vs. 37 months for N0 patients (p = 0.06). At the end of the follow-up period, nine patients had died from cancer recurrences (43%), three patients died from other reasons (14%), one patient was still alive with recurrence (5%) and the seven remaining patients were free of disease (33%). Recurrence was local (n = 3), metastatic (n = 3), or both (n = 4). In conclusion, carcinosarcoma and leiomyosarcoma were the most common esophageal sarcoma histological subtypes. Lymph node involvement was seen in one third of cases. A transthoracic en-bloc esophagectomy with radical lymphadenectomy should be the best surgical option to achieve complete resection. Long-term survival remained poor with a high local and distant recurrence rate.
7001 a Depypere, L4 aut
7001 a Piessen, G4 aut
7001 a Slaman, AE4 aut
7001 a Wijnhoven, BPL4 aut
7001 a Holscher, A4 aut
7001 a Nilsson, Mu Karolinska Institutet4 aut
7001 a Henegouwen, MIV4 aut
7001 a van Lanschot, JJB4 aut
7001 a Schroeder, W4 aut
7001 a Thomas, PA4 aut
7001 a Nafteux, P4 aut
7001 a D'Journo, XB4 aut
7102 a Karolinska Institutet4 org
7730 t Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagusd : Oxford University Press (OUP)g 31:3q 31:3x 1442-2050
7730 t Diseases of the Esophagusd : Oxford University Press (OUP)g 31:3q 31:3x 1120-8694
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:137918005
8564 8u https://doi.org/10.1093/dote/dox146

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