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Does depth of anest...
Does depth of anesthesia influence postoperative cognitive dysfunction or inflammatory response following major ENT surgery?
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- Jildenstål, Pether K., 1970- (författare)
- Department of Anesthesiology and Intensive Care, University Hospital, Örebro, Sweden
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- Hallén, Jan L. (författare)
- Department of Anesthesiology and Intensive Care, University Hospital, Örebro, Sweden
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- Rawal, Narinder (författare)
- Department of Anesthesiology and Intensive Care, University Hospital, Örebro, Sweden
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- Berggren, Lars, 1949- (författare)
- Department of Anesthesiology and Intensive Care, University Hospital, Örebro, Sweden; Centre for Assessment of Medical Technology (CAMTÖ), Region Örebro County, Örebro, Sweden
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(creator_code:org_t)
- OMICS Publishing Group, 2012
- 2012
- Engelska.
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Ingår i: Journal of Anesthesia & Clinical Research. - : OMICS Publishing Group. - 2155-6148. ; 3:6, s. 220-
- Relaterad länk:
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https://doi.org/10.4...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- The aim of this study was to evaluate the role of depth of anesthesia on POCD after major ENT surgery and to assess changes in postoperative inflammatory markers in patients undergoing major ENT surgery. Thirty two patients aged 40 to 94 yrs, scheduled for surgery under general anesthesia were randomly assigned to one of two groups. In group A (AEP group) depth of anesthesia (DOA) was measured with auditory evoked potential (AEP). In the control group (group C) DOA was monitored according to clinical signs. Cognitive function was evaluated using Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM) and Cognitive Failure Questionnaire (CFQ). Inflammatory markers were measured before and after anesthesia. Perioperative requirements for desflurane and fentanyl were significantly lower in group A. On the first postoperative day MMSE changes indicating POCD were noted in 1 patient in group A and 7 patients in group C (P<0.03). One month follow up did not show any difference between the groups regarding POCD. Our study indicates that AEP-guided anesthesia allows dose reduction of anesthetic agents including opioids leading to better cardiovascular stability and less early POCD. Anesthesia depth did not influence the inflammatory response to surgery.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Cognitive decline
- general anesthesia
- auditory evoked potential (AEP)
- Anestesiologi
- Anaesthesiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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