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Geosmin, a Food- and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1
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- Ball, Lena (författare)
- Tech Univ Munich, Germany
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- Frey, Tim (författare)
- Tech Univ Munich, Germany; Tecan Deutschland GmbH, Germany
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- Haag, Franziska (författare)
- Tech Univ Munich, Germany
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- AMER CHEMICAL SOC, 2024
- 2024
- Engelska.
- Ingår i: Journal of Agricultural and Food Chemistry. - : AMER CHEMICAL SOC. - 0021-8561 .- 1520-5118. ; 72:28, s. 15865-15874
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Geosmin, a ubiquitous volatile sesquiterpenoid of microbiological origin, is causative for deteriorating the quality of many foods, beverages, and drinking water, by eliciting an undesirable "earthy/musty" off-flavor. Moreover, and across species from worm to human, geosmin is a volatile, chemosensory trigger of both avoidance and attraction behaviors, suggesting its role as semiochemical. Volatiles typically are detected by chemosensory receptors of the nose, which have evolved to best detect ecologically relevant food-related odorants and semiochemicals. An insect receptor for geosmin was recently identified in flies. A human geosmin-selective receptor, however, has been elusive. Here, we report on the identification and characterization of a human odorant receptor for geosmin, with its function being conserved in orthologs across six mammalian species. Notably, the receptor from the desert-dwelling kangaroo rat showed a more than 100-fold higher sensitivity compared to its human ortholog and detected geosmin at low nmol/L concentrations in extracts from geosmin-producing actinomycetes.
Ämnesord
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Nyckelord
- olfaction; GPCR; high-throughput screening; sensor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Ball, Lena
- Frey, Tim
- Haag, Franziska
- Frank, Stephanie
- Hoffmann, Sandra
- Laska, Matthias
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- Steinhaus, Marti ...
- Neuhaus, Klaus
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