Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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Elks, Cathy E (author)

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Article/chapterEnglish2010

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2010-11-21
Springer Science and Business Media LLC,2010
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LIBRIS-ID:oai:DiVA.org:uu-223021
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223021URI
https://doi.org/10.1038/ng.714DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121622680URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

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Perry, John R B (author)
Sulem, Patrick (author)
Chasman, Daniel I (author)
Franceschini, Nora (author)
He, Chunyan (author)
Lunetta, Kathryn L (author)
Visser, Jenny A (author)
Byrne, Enda M (author)
Cousminer, Diana L (author)
Gudbjartsson, Daniel F (author)
Esko, Tõnu (author)
Feenstra, Bjarke (author)
Hottenga, Jouke-Jan (author)
Koller, Daniel L (author)
Kutalik, Zoltán (author)
Lin, Peng (author)
Mangino, Massimo (author)
Marongiu, Mara (author)
McArdle, Patrick F (author)
Smith, Albert V (author)
Stolk, Lisette (author)
van Wingerden, Sophie H (author)
Zhao, Jing Hua (author)
Albrecht, Eva (author)
Corre, Tanguy (author)
Ingelsson, Erik,1975-Karolinska Institutet(Swepub:uu)ering425 (author)
Hayward, Caroline (author)
Magnusson, Patrik K EKarolinska Institutet (author)
Smith, Erin N (author)
Ulivi, Shelia (author)
Warrington, Nicole M (author)
Zgaga, Lina (author)
Alavere, Helen (author)
Amin, Najaf (author)
Aspelund, Thor (author)
Bandinelli, Stefania (author)
Barroso, Inês (author)
Berenson, Gerald S (author)
Bergmann, Sven (author)
Blackburn, Hannah (author)
Boerwinkle, Eric (author)
Buring, Julie E (author)
Busonero, Fabio (author)
Campbell, Harry (author)
Chanock, Stephen J (author)
Chen, Wei (author)
Cornelis, Marilyn C (author)
Couper, David (author)
Coviello, Andrea D (author)
d'Adamo, Pio (author)
de Faire, UlfKarolinska Institutet (author)
de Geus, Eco J C (author)
Deloukas, Panos (author)
Döring, Angela (author)
Smith, George Davey (author)
Easton, Douglas F (author)
Eiriksdottir, Gudny (author)
Emilsson, Valur (author)
Eriksson, Johan (author)
Ferrucci, Luigi (author)
Folsom, Aaron R (author)
Foroud, Tatiana (author)
Garcia, Melissa (author)
Gasparini, Paolo (author)
Geller, Frank (author)
Gieger, Christian (author)
Gudnason, Vilmundur (author)
Hall, PerKarolinska Institutet (author)
Hankinson, Susan E (author)
Ferreli, Liana (author)
Heath, Andrew C (author)
Hernandez, Dena G (author)
Hofman, Albert (author)
Hu, Frank B (author)
Illig, Thomas (author)
Järvelin, Marjo-Riitta (author)
Johnson, Andrew D (author)
Karasik, David (author)
Khaw, Kay-Tee (author)
Kiel, Douglas P (author)
Kilpeläinen, Tuomas O (author)
Kolcic, Ivana (author)
Kraft, Peter (author)
Launer, Lenore J (author)
Laven, Joop S E (author)
Li, Shengxu (author)
Liu, Jianjun (author)
Levy, Daniel (author)
Martin, Nicholas G (author)
McArdle, Wendy L (author)
Melbye, Mads (author)
Mooser, Vincent (author)
Murray, Jeffrey C (author)
Murray, Sarah S (author)
Nalls, Michael A (author)
Navarro, Pau (author)
Nelis, Mari (author)
Ness, Andrew R (author)
Northstone, Kate (author)
Oostra, Ben A (author)
Peacock, Munro (author)
Palmer, Lyle J (author)
Palotie, Aarno (author)
Paré, Guillaume (author)
Parker, Alex N (author)
Pedersen, Nancy LKarolinska Institutet (author)
Peltonen, Leena (author)
Pennell, Craig E (author)
Pharoah, Paul (author)
Polasek, Ozren (author)
Plump, Andrew S (author)
Pouta, Anneli (author)
Porcu, Eleonora (author)
Rafnar, Thorunn (author)
Rice, John P (author)
Ring, Susan M (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Sala, Cinzia (author)
Salomaa, Veikko (author)
Sanna, Serena (author)
Schlessinger, David (author)
Schork, Nicholas J (author)
Scuteri, Angelo (author)
Segrè, Ayellet V (author)
Shuldiner, Alan R (author)
Soranzo, Nicole (author)
Sovio, Ulla (author)
Srinivasan, Sathanur R (author)
Strachan, David P (author)
Tammesoo, Mar-Liis (author)
Tikkanen, Emmi (author)
Toniolo, Daniela (author)
Tsui, Kim (author)
Tryggvadottir, Laufey (author)
Tyrer, Jonathon (author)
Uda, Manuela (author)
van Dam, Rob M (author)
van Meurs, Joyce B J (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Wareham, Nicholas J (author)
Waterworth, Dawn M (author)
Weedon, Michael N (author)
Wichmann, H Erich (author)
Willemsen, Gonneke (author)
Wilson, James F (author)
Wright, Alan F (author)
Young, Lauren (author)
Zhai, Guangju (author)
Zhuang, Wei Vivian (author)
Bierut, Laura J (author)
Boomsma, Dorret I (author)
Boyd, Heather A (author)
Crisponi, Laura (author)
Demerath, Ellen W (author)
van Duijn, Cornelia M (author)
Econs, Michael J (author)
Harris, Tamara B (author)
Hunter, David J (author)
Loos, Ruth J F (author)
Metspalu, Andres (author)
Montgomery, Grant W (author)
Ridker, Paul M (author)
Spector, Tim D (author)
Streeten, Elizabeth A (author)
Stefansson, Kari (author)
Thorsteinsdottir, Unnur (author)
Uitterlinden, André G (author)
Widen, Elisabeth (author)
Murabito, Joanne M (author)
Ong, Ken K (author)
Murray, Anna (author)
Karolinska Institutet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC42:12, s. 1077-851061-40361546-1718

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By the author/editor: Elks, Cathy E; Perry, John R B; Sulem, Patrick; Chasman, Daniel ...; Franceschini, No ...; He, Chunyan; show more...; Lunetta, Kathryn ...; Visser, Jenny A; Byrne, Enda M; Cousminer, Diana ...; Gudbjartsson, Da ...; Esko, Tõnu; Feenstra, Bjarke; Hottenga, Jouke- ...; Koller, Daniel L; Kutalik, Zoltán; Lin, Peng; Mangino, Massimo; Marongiu, Mara; McArdle, Patrick ...; Smith, Albert V; Stolk, Lisette; van Wingerden, S ...; Zhao, Jing Hua; Albrecht, Eva; Corre, Tanguy; Ingelsson, Erik, ...; Hayward, Carolin ...; Magnusson, Patri ...; Smith, Erin N; Ulivi, Shelia; Warrington, Nico ...; Zgaga, Lina; Alavere, Helen; Amin, Najaf; Aspelund, Thor; Bandinelli, Stef ...; Barroso, Inês; Berenson, Gerald ...; Bergmann, Sven; Blackburn, Hanna ...; Boerwinkle, Eric; Buring, Julie E; Busonero, Fabio; Campbell, Harry; Chanock, Stephen ...; Chen, Wei; Cornelis, Marily ...; Couper, David; Coviello, Andrea ...; d'Adamo, Pio; de Faire, Ulf; de Geus, Eco J C; Deloukas, Panos; Döring, Angela; Smith, George Da ...; Easton, Douglas ...; Eiriksdottir, Gu ...; Emilsson, Valur; Eriksson, Johan; Ferrucci, Luigi; Folsom, Aaron R; Foroud, Tatiana; Garcia, Melissa; Gasparini, Paolo; Geller, Frank; Gieger, Christia ...; Gudnason, Vilmun ...; Hall, Per; Hankinson, Susan ...; Ferreli, Liana; Heath, Andrew C; Hernandez, Dena ...; Hofman, Albert; Hu, Frank B; Illig, Thomas; Järvelin, Marjo- ...; Johnson, Andrew ...; Karasik, David; Khaw, Kay-Tee; Kiel, Douglas P; Kilpeläinen, Tuo ...; Kolcic, Ivana; Kraft, Peter; Launer, Lenore J; Laven, Joop S E; Li, Shengxu; Liu, Jianjun; Levy, Daniel; Martin, Nicholas ...; McArdle, Wendy L; Melbye, Mads; Mooser, Vincent; Murray, Jeffrey ...; Murray, Sarah S; Nalls, Michael A; Navarro, Pau; Nelis, Mari; Ness, Andrew R; Northstone, Kate; Oostra, Ben A; Peacock, Munro; Palmer, Lyle J; Palotie, Aarno; Paré, Guillaume; Parker, Alex N; Pedersen, Nancy ...; Peltonen, Leena; Pennell, Craig E; Pharoah, Paul; Polasek, Ozren; Plump, Andrew S; Pouta, Anneli; Porcu, Eleonora; Rafnar, Thorunn; Rice, John P; Ring, Susan M; Rivadeneira, Fer ...; Rudan, Igor; Sala, Cinzia; Salomaa, Veikko; Sanna, Serena; Schlessinger, Da ...; Schork, Nicholas ...; Scuteri, Angelo; Segrè, Ayellet V; Shuldiner, Alan ...; Soranzo, Nicole; Sovio, Ulla; Srinivasan, Sath ...; Strachan, David ...; Tammesoo, Mar-Li ...; Tikkanen, Emmi; Toniolo, Daniela; Tsui, Kim; Tryggvadottir, L ...; Tyrer, Jonathon; Uda, Manuela; van Dam, Rob M; van Meurs, Joyce ...; Vollenweider, Pe ...; Waeber, Gerard; Wareham, Nichola ...; Waterworth, Dawn ...; Weedon, Michael ...; Wichmann, H Eric ...; Willemsen, Gonne ...; Wilson, James F; Wright, Alan F; Young, Lauren; Zhai, Guangju; Zhuang, Wei Vivi ...; Bierut, Laura J; Boomsma, Dorret ...; Boyd, Heather A; Crisponi, Laura; Demerath, Ellen ...; van Duijn, Corne ...; Econs, Michael J; Harris, Tamara B; Hunter, David J; Loos, Ruth J F; Metspalu, Andres; Montgomery, Gran ...; Ridker, Paul M; Spector, Tim D; Streeten, Elizab ...; Stefansson, Kari; Thorsteinsdottir ...; Uitterlinden, An ...; Widen, Elisabeth; Murabito, Joanne ...; Ong, Ken K; Murray, Anna; show less...

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