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FoxP3+ T-Cells in Patients with B-Cell Chronic Lymphocytic Leukemia Express Cytolytic Markers and Kill Autologous B-Cells

Lindqvist, Camilla A (author)
Uppsala universitet,Enheten för klinisk immunologi
Christiansson, Lisa H (author)
Uppsala universitet,Enheten för klinisk immunologi
Mangsbo, Sara M (author)
Leiden University Medical Center
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Tötterman, Thomas H (author)
Uppsala universitet,Enheten för klinisk immunologi
Simonsson, Bengt (author)
Olsson-Strömberg, Ulla (author)
Loskog, Angelica SI (author)
Uppsala universitet,Enheten för klinisk immunologi
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 (creator_code:org_t)
English.
Related links:
https://urn.kb.se/re...
  • Other publication (other academic/artistic)
Abstract Subject headings
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  • Recent reports indicate that infiltration of FoxP3+ cells into the tumor area may be associated with better overall survival of patients with B-cell malignancies, which is in contrast to patients with non-hematopoetic tumors. Here, we demonstrate a possible mechanism to these findings. Since the tumor cell in lymphoma originates from the immune system we hypothesized that FoxP3+ T regulatory cells (Tregs) may have a suppressive role in tumor progression in patients with B-cell malignancies. Peripheral blood was collected from 14 patients with B-cell chronic lymphocytic leukemia (B-CLL) and their Tregs were evaluated for cytolytic markers such as FasL and CD107a. We found that both conventional Tregs (CD4+ FoxP3+CD127low T-cells) and FoxP3+CD127high T-cells were significantly increased in patients with B-CLL compared to healthy controls. Further, both groups of FoxP3+ cells displayed higher expression of the degranulation marker CD107a indicating perforin/granzyme release. A flow cytometry-based cytotoxicity assay demonstrated that purified Tregs  from both patients and healthy controls could kill autologous B-cells in vitro. In conclusion, FoxP3+ T-cells in patients with CLL show effector phenotype and may be involved in tumor cell control by their natural capacity to kill B-cells.

Keyword

T regulatory cells
FoxP3
chronic lymphocytic leukemia
CD107a
effector Treg
cytotoxic Treg
Immunologi
Immunology

Publication and Content Type

vet (subject category)
ovr (subject category)

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