Sökning: WFRF:(Magnusson Yvonne) > Androgens in women ...
Fältnamn | Indikatorer | Metadata |
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000 | 05266naa a2200541 4500 | |
001 | oai:lup.lub.lu.se:f4d1ce3b-09cf-47ac-b444-5c9872e64aa3 | |
003 | SwePub | |
008 | 170317s2017 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/248549 | |
024 | 7 | a https://lup.lub.lu.se/record/f4d1ce3b-09cf-47ac-b444-5c9872e64aa32 URI |
024 | 7 | a https://doi.org/10.1038/bmt.2016.2682 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/2485492 URI |
040 | a (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Björk, Yvonneu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xbjoyv |
245 | 1 0 | a Androgens in women after allogeneic hematopoietic cell transplantation : Impact of chronic GvHD and glucocorticoid therapy |
264 | c 2016-12-12 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
300 | a 7 s. | |
520 | a Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26). Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups; P<0.0001 and P<0.05, respectively. Androgens in the autoHCT group were similar or higher than controls. In the subgroup of alloHCT patients without cGvHD, free T was similar to controls (7.2 vs 8.6 pmol/L; P=0.42), whereas DHEAS levels was lower than controls (1.7 vs 2.5 μmol/L; P=0.008). Compared with controls, cGvHD without GC (n=10) was associated with lower free T and DHEAS; P=0.004 and P=0.0004, respectively). The lowest androgen levels were seen in women with both cGvHD and GC therapy. In conclusion, low serum androgens were associated with cGvHD and GC therapy, prompting for studies assessing a possible association between low androgens and sexual dysfunction and quality of life in allografted women. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a androgens | |
653 | a women | |
653 | a allogeneic hematopoietic | |
653 | a glucocorticoid therapy | |
700 | 1 | a Smith Knutsson, E.u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut |
700 | 1 | a Ankarberg-Lindgren, Carina,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xankca |
700 | 1 | a Broman, A. K.u Sahlgrenska Academy4 aut |
700 | 1 | a Andersson, I.u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:lu)ront-ian |
700 | 1 | a Björkman, L.u Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xblenv |
700 | 1 | a Magnusson, J.u Sahlgrenska University Hospital4 aut |
700 | 1 | a Bergmark, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xbkari |
700 | 1 | a Anderson, H.u Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-han |
700 | 1 | a Andersson, Per O.u South Älvsborg Hospital, Sahlgrenska Academy4 aut |
700 | 1 | a Brune, Mats,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xbrunm |
710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
773 | 0 | t Bone Marrow Transplantationd : Springer Science and Business Media LLCg 52:3, s. 431-437q 52:3<431-437x 0268-3369x 1476-5365 |
856 | 4 | u http://dx.doi.org/10.1038/bmt.2016.268y FULLTEXT |
856 | 4 | u https://www.nature.com/articles/bmt2016268.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/f4d1ce3b-09cf-47ac-b444-5c9872e64aa3 |
856 | 4 8 | u https://doi.org/10.1038/bmt.2016.268 |
856 | 4 8 | u https://gup.ub.gu.se/publication/248549 |
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