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Tofacitinib real-wo...
Tofacitinib real-world experience in ulcerative colitis in Finland (FinTofUC) : a retrospective non-interventional multicenter patient chart data study
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- Molander, Pauliina (författare)
- Univ Helsinki, Abdominal Ctr, Gastroenterol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Abdominal Ctr, Gastroenterol, Helsinki, Finland.
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- Kosunen, Mikko (författare)
- Pfizer Oy, Helsinki, Finland.
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- Eronen, Heli (författare)
- Kanta Hame Cent Hosp, Dept Internal Med, Hameenlinna, Finland.
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- Tillonen, Jyrki (författare)
- Paijat Hame Cent Hosp, Dept Internal Med, Lahti, Finland.
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- Käräjämäki, Aki (författare)
- Vaasa Cent Hosp, Dept Internal Med, Vaasa, Finland.
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- Heikkinen, Markku (författare)
- Kuopio Univ Hosp, Dept Internal Med, Kuopio, Finland.
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- Punkkinen, Jari (författare)
- Univ Helsinki, Abdominal Ctr, Gastroenterol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Mattila, Riikka (författare)
- Medaffcon Oy, Espoo, Finland.
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- Toppila, Iiro (författare)
- Medaffcon Oy, Espoo, Finland.
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- Hölsä, Olivia (författare)
- Medaffcon Oy, Espoo, Finland.
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- Kalpala, Kirsi (författare)
- Pfizer Oy, Helsinki, Finland.
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- Henrohn, Dan (författare)
- Uppsala universitet,Reumatologi,Kardiologi,Pfizer AB, Stockholm, Sweden
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- af Björkesten, Clas-Göran (författare)
- Univ Helsinki, Abdominal Ctr, Gastroenterol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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Univ Helsinki, Abdominal Ctr, Gastroenterol, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Abdominal Ctr, Gastroenterol, Helsinki, Finland. Pfizer Oy, Helsinki, Finland. (creator_code:org_t)
- Taylor & Francis, 2024
- 2024
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 59:4, s. 425-432
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- ObjectivesThe aim was to define the effectiveness of tofacitinib and to characterize the patient population receiving tofacitinib in a real-world cohort clinical setting for ulcerative colitis (UC) in Finland.MethodsThis is a retrospective non-interventional multicenter patient chart data study conducted in 23 Finnish Inflammatory Bowel Disease (IBD) centers. Baseline demographic and clinical data, clinical remission, steroid-free remission rate and time to tofacitinib discontinuation, colectomy or UC-related hospitalization were studied.ResultsThe study included 252 UC patients of which 69% were male. Most patients had extensive disease (71%) and were bio-experienced (81%). Tofacitinib demonstrated positive treatment outcomes with clinical response, clinical remission, and steroid-free clinical remission at one year in 33%, 34% and 31% of patients, respectively. Moreover, 64% of patients in pMayo remission at week 16 from the start of tofacitinib were still in remission at one year. Only no or mild disease activity compared to moderate activity at baseline was associated with a higher probability of achieving remission according to pMayo at six months, p = .008. Hospitalizations and/or colectomies during the study period (before treatment discontinuation/end of follow-up) were low (n = 24), with less than 5 colectomies.ConclusionsIn this real-world cohort, including a majority of bio-experienced UC patients, tofacitinib was effective in achieving steroid-free clinical remission in a third of the population at one year. A majority of patients in remission at week 16 were also in remission at one year. Results are in line with earlier published real-world studies. Registration: ClinicalTrials.gov NCT05082428.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Inflammatory bowel disease
- ulcerative colitis
- tofacitinib
- treatment outcome
- real-world evidence
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Molander, Paulii ...
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Kosunen, Mikko
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Eronen, Heli
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Tillonen, Jyrki
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Käräjämäki, Aki
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Heikkinen, Markk ...
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visa fler...
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Punkkinen, Jari
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Mattila, Riikka
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Toppila, Iiro
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Hölsä, Olivia
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Kalpala, Kirsi
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Henrohn, Dan
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af Björkesten, C ...
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