WFRF:(Mitsakakis K)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02869naa a2200445 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:144980031 | |
| 003 | SwePub | |
| 008 | 240916s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1449800312 URI |
| 024 | 7 | a https://doi.org/10.3390/jcm90929452 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Paque, PN4 aut |
| 245 | 1 0 | a Microbial Analysis of Saliva to Identify Oral Diseases Using a Point-of-Care Compatible qPCR Assay |
| 264 | c 2020-09-11 | |
| 264 | 1 | b MDPI AG,c 2020 |
| 520 | a Oral health is maintained by a healthy microbiome, which can be monitored by state-of-the art diagnostics. Therefore, this study evaluated the presence and quantity of ten oral disease-associated taxa (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, C. rectus, P. intermedia, A. actinomycetemcomitans, S. mutans, S. sobrinus, oral associated Lactobacilli) in saliva and their clinical status association in 214 individuals. Upon clinical examination, study subjects were grouped into healthy, caries and periodontitis and their saliva was collected. A highly specific point-of-care compatible dual color qPCR assay was developed and used to study the above-mentioned bacteria of interest in the collected saliva. Assay performance was compared to a commercially available microbial reference test. Eight out of ten taxa that were investigated during this study were strong discriminators between the periodontitis and healthy groups: C. rectus, T. forsythia, P. gingivalis, S. mutans, F. nucleatum, T. denticola, P. intermedia and oral Lactobacilli (p < 0.05). Significant differentiation between the periodontitis and caries group microbiome was only shown for S. mutans (p < 0.05). A clear distinction between oral health and disease was enabled by the analysis of quantitative qPCR data of target taxa levels in saliva. | |
| 700 | 1 | a Herz, C4 aut |
| 700 | 1 | a Jenzer, JS4 aut |
| 700 | 1 | a Wiedemeier, DB4 aut |
| 700 | 1 | a Attin, T4 aut |
| 700 | 1 | a Bostanci, Nu Karolinska Institutet4 aut |
| 700 | 1 | a Belibasakis, GNu Karolinska Institutet4 aut |
| 700 | 1 | a Bao, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Korner, P4 aut |
| 700 | 1 | a Fritz, T4 aut |
| 700 | 1 | a Prinz, J4 aut |
| 700 | 1 | a Schmidlin, PR4 aut |
| 700 | 1 | a Thurnheer, T4 aut |
| 700 | 1 | a Wegehaupt, FJ4 aut |
| 700 | 1 | a Mitsakakis, K4 aut |
| 700 | 1 | a Peham, JR4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Journal of clinical medicined : MDPI AGg 9:9q 9:9x 2077-0383 |
| 856 | 4 | u https://www.mdpi.com/2077-0383/9/9/2945/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144980031 |
| 856 | 4 8 | u https://doi.org/10.3390/jcm9092945 |
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- Paque, PN
- Herz, C
- Jenzer, JS
- Wiedemeier, DB
- Attin, T
- Bostanci, N
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- Belibasakis, GN
- Bao, K
- Korner, P
- Fritz, T
- Prinz, J
- Schmidlin, PR
- Thurnheer, T
- Wegehaupt, FJ
- Mitsakakis, K
- Peham, JR
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