CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

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Fältnamn	Indikatorer	Metadata
000		03413naa a2200565 4500
001		oai:DiVA.org:su-110749
003		SwePub
008		141217s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1107492 URI
024	7	a https://doi.org/10.1016/j.celrep.2014.09.0452 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fergusson, Joannah R.4 aut
245	1 0	a CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages
264	1	b Elsevier BV,c 2014
338		a print2 rdacarrier
500		a AuthorCount:22;
520		a The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell transcriptional signature enriched in CD161+CD8+ T cells, which can be extended to CD161+ CD4+ and CD161+TCR gamma delta+ T cells. Furthermore, this led to the identification of a shared innate-like, TCR-independent response to interleukin (IL)-12 plus IL-18 by different CD161-expressing T cell populations. This response was independent of regulation by CD161, which acted as a costimulatory molecule in the context of T cell receptor stimulation. Expression of CD161 hence identifies a transcriptional and functional phenotype, shared across human T lymphocytes and independent of both T cell receptor (TCR) expression and cell lineage.
650	7	a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
700	1	a Smith, Kira E.4 aut
700	1	a Fleming, Vicki M.4 aut
700	1	a Rajoriya, Neil4 aut
700	1	a Newell, Evan W.4 aut
700	1	a Simmons, Ruth4 aut
700	1	a Marchi, Emanuele4 aut
700	1	a Björkander, Sophiau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)sobj9073
700	1	a Kang, Yu-Hoi4 aut
700	1	a Swadling, Leo4 aut
700	1	a Kurioka, Ayako4 aut
700	1	a Sahgal, Natasha4 aut
700	1	a Lockstone, Helen4 aut
700	1	a Baban, Dilair4 aut
700	1	a Freeman, Gordon J.4 aut
700	1	a Sverremark-Ekström, Evau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)esver
700	1	a Davis, Mark M.4 aut
700	1	a Davenport, Miles P.4 aut
700	1	a Venturi, Vanessa4 aut
700	1	a Ussher, James E.4 aut
700	1	a Willberg, Christian B.4 aut
700	1	a Klenerman, Paul4 aut
710	2	a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org
773	0	t Cell Reportsd : Elsevier BVg 9:3, s. 1075-1088q 9:3<1075-1088x 2211-1247
856	4	u https://doi.org/10.1016/j.celrep.2014.09.045y Fulltext
856	4	u https://doi.org/10.1016/j.celrep.2014.09.045
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-110749
856	4 8	u https://doi.org/10.1016/j.celrep.2014.09.045

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