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Effects of smoking ...
Effects of smoking cessation on beta cell function, insulin sensitivity, body weight and appetite.
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Stadler, Marietta (author)
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Tomann, Larissa (author)
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Storka, Angela (author)
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Wolzt, Michael (author)
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Peric, Slobodan (author)
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Bieglmayer, Christian (author)
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Pacini, Giovanni (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Brath, Helmut (author)
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Bech, Paul (author)
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Prager, Rudolf (author)
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Korbonits, Marta (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: European journal of endocrinology / European Federation of Endocrine Societies. - 1479-683X. ; 170, s. 219-227
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objective To stop smoking is commonly associated with significant weight gain, but the mechanisms for this are poorly understood. We assessed the effects of smoking cessation on body weight, insulin sensitivity, β-cell function, and appetite. Subjects and methods Twenty-seven long-term smokers (n=27; nine females/18 males, 28±1 years, 22.9±0.6kg/m2) attending an ambulatory smoking cessation program in a community hospital in Vienna, Austria were examined at baseline (Visit A; still smoking) and after a minimum of 3 months of smoking abstinence (Visit B; n=14); relapsed smokers were not followed up. Participants underwent 3-h oral glucose tolerance tests and body composition measurements at each study visit. Fasting (QUICKI) and dynamic (oral glucose insulin sensitivity (OGIS)) insulin sensitivity and β-cell secretion (insulinogenic index 140 (IGI40)) were calculated. Food intake was quantified with a free choice buffet. Fasting plasma concentrations of neuropeptide-Y (NPY), peptide-YY (PYY), glucagon-like peptide 1 (GLP1), leptin, ghrelin, and visfatin were measured. Results After >3 months' smoking abstinence, body weight, and fat mass were increased (+4 and +22% respectively, P<0.05) and fasting insulin sensitivity deteriorated (QUICKI: post, 0.37±0.02 vs baseline, 0.41±0.2; P<0.05), while OGIS remained unchanged throughout. IGI40 increased by 31% after >3 months' smoking abstinence (P<0.01). Carbohydrate ingestion increased after stopping smoking (P<0.05). NPY fasting levels were increased after >3 months (P<0.05), PYY, GLP1, leptin, ghrelin, and visfatin were unchanged. Conclusion Smoking cessation is associated with transient metabolic changes including increased β-cell secretion in response to glucose and fasting insulin resistance. These alterations may be associated with or contribute to the body weight gain after smoking cessation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- smoking
- body weight
- obesity
- gherkin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stadler, Mariett ...
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Tomann, Larissa
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Storka, Angela
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Wolzt, Michael
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Peric, Slobodan
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Bieglmayer, Chri ...
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show more...
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Pacini, Giovanni
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Dickson, Suzanne ...
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Brath, Helmut
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Bech, Paul
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Prager, Rudolf
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Korbonits, Marta
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg