Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems

Chudinova, E.National Research Tomsk Polytechnic University, Tomsk, Russian Federation (författare)

In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.

Surmeneva, M.National Research Tomsk Polytechnic University, Tomsk, Russian Federation (författare)
Koptioug, Andrei,1956-Mittuniversitetet,Institutionen för kvalitets- och maskinteknik(Swepub:miun)andkop (författare)
Sokolova, V.University of Duisburg-Essen, Essen, Germany (författare)
Prymak, O.University of Duisburg-Essen, Essen, Germany (författare)
Bouckercha, S.University of Duisburg-Essen, Essen, Germany (författare)
Epple, M.University of Duisburg-Essen, Essen, Germany (författare)
Surmenev, R.National Research Tomsk Polytechnic University, Tomsk, Russian Federation (författare)
National Research Tomsk Polytechnic University, Tomsk, Russian FederationInstitutionen för kvalitets- och maskinteknik (creator_code:org_t)

Av författaren/redakt...: Chudinova, E.; Surmeneva, M.; Koptioug, Andrei ...; Sokolova, V.; Prymak, O.; Bouckercha, S.; visa fler...; Epple, M.; Surmenev, R.; visa färre...

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