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Sökning: WFRF:(Ridell Malin 1942) > LosA, a key glycosy...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003712naa a2200577 4500
001oai:gup.ub.gu.se/54349
003SwePub
008240910s2005 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/543492 URI
0247 a https://doi.org/10.1074/jbc.M5075002002 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Burguière, Adeline4 aut
2451 0a LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.
264 1c 2005
520 a Members of the genus Mycobacterium are characterized by cell envelopes rich in unusual free lipids, interacting with a covalently anchored mycolyl-arabinogalactan matrix. Previous studies have shown that Mycobacterium marinum produces large amounts of a diacylglycosylphenolphthiocerol, "phenolic" glycolipid. When cultivated on liquid Sauton medium, traces of a polar lipooligosaccharide (LOS) glycolipid antigen were also previously indicated. In this study, it was found that growth of the type strain of M. marinum on solid Sauton or Middlebrook 7H10 agar gave substantial, but different, amounts of a family of four major trehalose-based LOSs. The core pentasaccharide LOS-I was a rhamnosyl diglucosyl-acylated trehalose. The heptasaccharide, LOS-II, was derived from LOS-I by adding xylose accompanied by a novel sugar (X); repeated addition of this sugar unit X gave the octasaccharide LOS-III. LOS-IV has a decasaccharide component with two additional unusual sugar units, YZ. In a recent study (Alexander, D. C., Jones, J. R., Tan, T., Chen, J. M., and Liu, J. (2004) J. Biol. Chem. 279, 18824-18833), chromatographically similar glycolipids were assigned to the family of phosphatidylinositol mannosides (PIMs) and a "PimF" (Rv1500) glycosyltransferase implicated in the conversion of a supposed "PIM5" to a "PIM7." The present study indicates that these putative PIMs are in fact members of the phosphorus-free LOS family of glycolipids and that the protein product of Rv1500, which we have now termed LosA, is a glycosyltransferase involved in transferring sugars to LOS-III to form LOS-IV of M. marinum.
653 a Base Sequence
653 a Carbohydrate Sequence
653 a Chromatography
653 a Thin Layer
653 a DNA Primers
653 a Glycosyltransferases
653 a metabolism
653 a Lipopolysaccharides
653 a biosynthesis
653 a chemistry
653 a Molecular Sequence Data
653 a Mycobacterium marinum
653 a enzymology
653 a growth & development
653 a metabolism
653 a Spectrometry
653 a Mass
653 a Matrix-Assisted Laser Desorption-Ionization
7001 a Hitchen, Paul G4 aut
7001 a Dover, Lynn G4 aut
7001 a Kremer, Laurent4 aut
7001 a Ridell, Malin,d 1942u Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology4 aut0 (Swepub:gu)xridma
7001 a Alexander, David C4 aut
7001 a Liu, Jun4 aut
7001 a Morris, Howard R4 aut
7001 a Minnikin, David E4 aut
7001 a Dell, Anne4 aut
7001 a Besra, Gurdyal S4 aut
7102 a Göteborgs universitetb Institutionen för medicinsk mikrobiologi och immunologi4 org
7730 t The Journal of biological chemistryg 280:51, s. 42124-33q 280:51<42124-33x 0021-9258
8564 8u https://gup.ub.gu.se/publication/54349
8564 8u https://doi.org/10.1074/jbc.M507500200

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