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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03062naa a2200325 4500 | |
| 001 | oai:gup.ub.gu.se/166356 | |
| 003 | SwePub | |
| 008 | 240528s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1663562 URI |
| 024 | 7 | a https://doi.org/10.1016/j.thromres.2012.08.3152 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Eriksson, Bengt I.,d 1946u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics4 aut0 (Swepub:gu)xerben |
| 245 | 1 0 | a Efficacy of delayed thromboprophylaxis with dabigatran: Pooled analysis. |
| 264 | 1 | b Elsevier BV,c 2012 |
| 520 | a INTRODUCTION: Oral thromboprophylaxis with dabigatran etexilate should be initiated as a half dose 1 to 4h after major orthopaedic surgery. However, a delay in dosing could occur for clinical or logistical reasons. A post hoc analysis was carried out to determine if patients with delayed dosing received adequate anticoagulation. PATIENTS AND METHODS: The RE-MODEL™ and RE-NOVATE® trials compared 220mg and 150mg dabigatran etexilate with 40mg enoxaparin. Pooled data for major venous thromboembolism (VTE) and VTE-related mortality (efficacy outcome) and major bleeding events (MBE), MBE/clinically relevant bleeding events, and all bleeding events (safety outcomes) were analysed. Results in patients with dosing delayed more than 4h postsurgery were compared with those of patients without a delay. RESULTS: Onset of treatment was delayed in 724 (13.3%) of 5425 patients. Efficacy of 220mg dabigatran etexilate was similar in patients without delayed dosing, patients with a delay and patients with a delay until the day after surgery. Rates of efficacy outcome were higher in patients on 150mg dabigatran etexilate, but more than 80% of these patients were undertreated based on age or renal clearance status. Some differences in bleeding events were seen among patient groups by treatment arm. CONCLUSION: Dabigatran etexilate thromboprophylaxis should be initiated 1 to 4h postsurgery. Results from our post-hoc analysis indicate that no loss of efficacy appears to occur if initiation of dabigatran etexilate 220mg needs to be delayed. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 700 | 1 | a Dahl, Ola E4 aut |
| 700 | 1 | a Rosencher, Nadia4 aut |
| 700 | 1 | a Clemens, Andreas4 aut |
| 700 | 1 | a Hantel, Stefan4 aut |
| 700 | 1 | a Kurth, Andreas A4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för ortopedi4 org |
| 773 | 0 | t Thrombosis researchd : Elsevier BVg 130:6, s. 871-876q 130:6<871-876x 1879-2472x 0049-3848 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/166356 |
| 856 | 4 8 | u https://doi.org/10.1016/j.thromres.2012.08.315 |
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- Dahl, Ola E
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- Clemens, Andreas
- Hantel, Stefan
- Kurth, Andreas A
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
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