Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes

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Fältnamn	Indikatorer	Metadata
000		02722naa a2200397 4500
001		oai:DiVA.org:uu-509176
003		SwePub
008		230816s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5091762 URI
024	7	a https://doi.org/10.1101/2022.09.14.5067922 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Schutzer, Steven E.4 aut
245	1 0	a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes
264		c 2022
264	1	b Cold Spring Harbor Laboratory Press (CSHL),c 2022
338		a print2 rdacarrier
520		a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue. This has given rise to the question whether they are distinct central nervous system (CNS) entities or is one an extension of the other. To investigate this, we used unbiased quantitative mass spectrometry-based proteomics to examine the most proximal fluid to the brain, cerebrospinal fluid (CSF). This was to ascertain if the proteome profile of one was the same or different from the other. We examined two separate groups of ME/CFS, one with (n=15) and one without (n=15) fibromyalgia. We quantified a total of 2,083 proteins using immunoaffinity depletion, tandem mass tag isobaric labeling and offline two-dimensional liquid chromatography coupled to tandem mass spectrometry, including 1,789 that were quantified in all the CSF samples. ANOVA analysis did not yield any proteins with an adjusted p-value < 0.05. This supports the notion that ME/CFS and fibromyalgia as currently defined are not distinct entities.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Liu, Tao4 aut
700	1	a Tsai, Chia-Feng4 aut
700	1	a Petyuk, Vladislav A.4 aut
700	1	a Schepmoes, Athena A.4 aut
700	1	a Wang, Yi-Ting4 aut
700	1	a Weitz, Karl K.4 aut
700	1	a Bergquist, Jonasu Uppsala universitet,Analytisk kemi4 aut0 (Swepub:uu)jbe25356
700	1	a Smith, Richard D.4 aut
700	1	a Natelson, Benjamin H4 aut
710	2	a Uppsala universitetb Analytisk kemi4 org
773	0	t bioRxiv Neurologyd : Cold Spring Harbor Laboratory Press (CSHL)
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-509176
856	4 8	u https://doi.org/10.1101/2022.09.14.506792

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Av författaren/redakt...: Schutzer, Steven ...; Liu, Tao; Tsai, Chia-Feng; Petyuk, Vladisla ...; Schepmoes, Athen ...; Wang, Yi-Ting; visa fler...; Weitz, Karl K.; Bergquist, Jonas; Smith, Richard D ...; Natelson, Benjam ...; visa färre...

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Av lärosätet: Uppsala universitet

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