Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.

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Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.

Duarte-Salles, Talita (author)

Vizcaya, David (author)

Pistillo, Andrea (author)

Casajust, Paula (author)

Sena, Anthony G (author)

Lai, Lana Yin Hui (author)

Prats-Uribe, Albert (author)

Ahmed, Waheed-Ul-Rahman (author)

Alshammari, Thamir M (author)

Alghoul, Heba (author)

Alser, Osaid (author)

Burn, Edward (author)

You, Seng Chan (author)

Areia, Carlos (author)

Blacketer, Clair (author)

DuVall, Scott (author)

Falconer, Thomas (author)

Fernandez-Bertolin, Sergio (author)

Fortin, Stephen (author)

Golozar, Asieh (author)

Gong, Mengchun (author)

Tan, Eng Hooi (author)

Huser, Vojtech (author)

Iveli, Pablo (author)

Morales, Daniel R (author)

Nyberg, Fredrik, 1961 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine

Posada, Jose D (author)

Recalde, Martina (author)

Roel, Elena (author)

Schilling, Lisa M (author)

Shah, Nigam H (author)

Shah, Karishma (author)

Suchard, Marc A (author)

Zhang, Lin (author)

Zhang, Ying (author)

Williams, Andrew E (author)

Reich, Christian G (author)

Hripcsak, George (author)

Rijnbeek, Peter (author)

Ryan, Patrick (author)

Kostka, Kristin (author)

Prieto-Alhambra, Daniel (author)

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(creator_code:org_t)

2021-09-01
2021
English.
In: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 148:3

Related links:: https://publications...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018.International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.A total of 242158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2084180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

Adolescent
Age Distribution
COVID-19
complications
diagnosis
drug therapy
epidemiology
Child
Child
Preschool
Cohort Studies
Comorbidity
Databases
Factual
Diagnosis
Differential
Female
France
epidemiology
Germany
epidemiology
Hospitalization
statistics & numerical data
Humans
Infant
Infant
Newborn
Influenza
Human
complications
diagnosis
epidemiology
Male
Republic of Korea
epidemiology
Spain
epidemiology
Symptom Assessment
Time Factors
Treatment Outcome
United States
epidemiology

Publication and Content Type

ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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By the university: University of Gothenburg

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