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An Aggregated Comor...
An Aggregated Comorbidity Measure Based on History of Filled Drug Prescriptions : Development and Evaluation in Two Separate Cohorts
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- Gedeborg, Rolf (författare)
- Uppsala universitet,Anestesiologi och intensivvård,From the Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Umea Univ, Dept Surg & Perioperat Sci, Dept Surg & Perioperat Surg, Umea, Sweden.
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- Lambe, Mats (författare)
- Karolinska Institutet
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- Plym, Anna (författare)
- Karolinska Institutet
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- Fredriksson, Irma (författare)
- Karolinska Institutet
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- Syrjä, Johan (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,From the Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Holmberg, Lars (författare)
- Uppsala universitet,Endokrinkirurgi,Guys Hosp, Translat Oncol & Urol Res, Kings Coll London, London, England.,From the Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Translational Oncology and Urology Research (TOUR), King's College London, Guy's Hospital, London, United Kingdom
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- Robinson, David (författare)
- Ryhov Hosp, Dept Urol, Jonkoping, Sweden.,Department of Urology, Ryhov Hospital, Sweden
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- Stattin, Pär (författare)
- Uppsala universitet,Urologkirurgi,From the Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Garmo, Hans (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Guys Hosp, Translat Oncol & Urol Res, Kings Coll London, London, England.;Univ Uppsala Hosp, Reg Canc Ctr Uppsala, Reg Canc Ctr Orebro, Uppsala, Sweden.,From the Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Translational Oncology and Urology Research (TOUR), King's College London, Guy's Hospital, London, United Kingdom; Regional Cancer Center, Uppsala/Örebro, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2021
- 2021
- Engelska.
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Ingår i: Epidemiology. - : Lippincott Williams & Wilkins. - 1044-3983 .- 1531-5487. ; 32:4, s. 607-615
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The ability to account for comorbidity when estimating survival in a population diagnosed with cancer could be improved by using a drug comorbidity index based on filled drug prescriptions.Methods: We created a drug comorbidity index from age-stratified univariable associations between filled drug prescriptions and time to death in 326,450 control males randomly selected from the general population to men with prostate cancer. We also evaluated the index in 272,214 control females randomly selected from the general population to women with breast cancer.Results: The new drug comorbidity index predicted survival better than the Charlson Comorbidity Index (CCI) and a previously published prescription index during 11 years of follow-up. The concordance (C)-index for the new index was 0.73 in male and 0.76 in the female population, as compared with a C-index of 0.67 in men and 0.69 in women for the CCI. In men of age 75-84 years with CCI = 0, the median survival time was 7.1 years (95% confidence interval [CI] = 7.0, 7.3) in the highest index quartile. Comparing the highest to the lowest drug comorbidity index quartile resulted in a hazard ratio (HR) of 2.2 among men (95% CI = 2.1, 2.3) and 2.4 among women (95% CI = 2.3, 2.6).Conclusions: A new drug comorbidity index based on filled drug prescriptions improved prediction of survival beyond age and the CCI alone. The index will allow a more accurate baseline estimation of expected survival for comparing treatment outcomes and evaluating treatment guidelines in populations of people with cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- ATC code
- Breast cancer
- Cancer
- Comorbidity
- Medicines
- Mortality
- Prescriptions
- Prostate cancer
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Gedeborg, Rolf
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Sund, Malin
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Lambe, Mats
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Plym, Anna
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Fredriksson, Irm ...
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Syrjä, Johan
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Holmberg, Lars
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Robinson, David
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Stattin, Pär
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Garmo, Hans
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Epidemiology
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet