Sökning: WFRF:(Sydes M R) > The spotted gar gen...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 12934naa a2201057 4500 | |
001 | oai:DiVA.org:uu-293022 | |
003 | SwePub | |
008 | 160511s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2930222 URI |
024 | 7 | a https://doi.org/10.1038/ng.35262 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Braasch, Ingou Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.;Michigan State Univ, Dept Integrat Biol, E Lansing, MI 48824 USA.4 aut |
245 | 1 0 | a The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons |
264 | c 2016-03-07 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
500 | a Funding: We thank the Broad Institute Genomics Platform for constructing and sequencing gar DNA and RNA libraries and J. Turner-Maier for the gar transcriptome assembly. We thank the teams of the Bayousphere Research Laboratory (Nicholls State University) and the University of Oregon Fish Facility for gar work and husbandry. We thank J. Westlund for the design of the species illustrations. The generation of gar sequences and assemblies by the Broad Institute of MIT and Harvard University was supported by US National Institutes of Health (NIH)/National Human Genome Research Institute grant U54 HG03067. This work was further supported by US NIH grants R01 OD011116 (alias R01 RR020833) and R24 OD01119004 (J.H.P.); a Feodor Lynen Fellowship from the Alexander von Humboldt Foundation and the Volkswagen Foundation Initiative Evolutionary Biology, grant I/84 815 (I.B.); US NIH grant T32 HD055164 and National Science Foundation (NSF) Doctoral Dissertation Improvement Grant 1311436 (A.R.G.); Uehara Memorial Foundation Research Fellowship 2013, Japan Society for the Promotion of Science Postdoctoral Research Fellowship 2012-127 and Marine Biological Laboratory Research Award 2014 (T.N.); Brazilian National Council for Scientific and Technological Development (CNPq) grants 402754/2012-3 and 477658/2012-1 (I.S.); the Brinson Foundation and the University of Chicago Biological Sciences Division (N.H.S.); NSF grant BCS0725227 (K.K.); call 'ARISTEIA I' of the National Strategic Reference Framework 2007-2013 (SPARCOMP, 36), Ministry of Education and Religious Affairs of Greece (T.M.); Agence Nationale de la Recherche (ANR) grant ANR-10-GENM-017 (PhyloFish; J.B.); the Wellcome Trust (grants WT095908 and WT098051) and the European Molecular Biology Laboratory (D.B., S.M.J.S. and B.A.); the Biomedical Research Council of the Agency for Science, Technology and Research (A*STAR), Singapore (B.V.); European Research Council grant 268513 (P.W.H.H. and K.J.M.); the Ministerio de Ciencia e Innovacion (BFU2010-14875 and BFU2015-71340) and the Generalitat de Catalunya, AGAUR (SGR2014-290) (C. C.); US NIH grant R01 AI057559 (G.W.L. and J.A.Y.); US NIH grants R24 OD010922 and R01 GM079492 (C. T. A.); and the National Basic Research Program of China (973 Program) (2012CB947600) and the National Natural Science Foundation of China (NSFC) (31030062) (H.W.). | |
520 | a To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Gehrke, Andrew R.u Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USA.4 aut |
700 | 1 | a Smith, Jeramiah J.u Univ Kentucky, Dept Biol, Lexington, KY USA.4 aut |
700 | 1 | a Kawasaki, Kazuhikou Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.4 aut |
700 | 1 | a Manousaki, Terezau Hellen Ctr Marine Res, Inst Marine Biol Biotechnol & Aquaculture, Iraklion, Greece.4 aut |
700 | 1 | a Pasquier, Jeremyu INRA, LPGP, UR1037, Campus Beaulieu, F-35042 Rennes, France.4 aut |
700 | 1 | a Amores, Angelu Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
700 | 1 | a Desvignes, Thomasu Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
700 | 1 | a Batzel, Peteru Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
700 | 1 | a Catchen, Julianu Univ Illinois, Dept Anim Biol, Urbana, IL 61801 USA.4 aut |
700 | 1 | a Berlin, Aaron M.u MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.4 aut |
700 | 1 | a Campbell, Michael S.u Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT USA.;Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA.4 aut |
700 | 1 | a Barrell, Danielu Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.;European Bioinformat Inst, European Mol Biol Lab, Wellcome Trust Genome Campus, Hinxton, England.4 aut |
700 | 1 | a Martin, Kyle J.u Univ Oxford, Dept Zool, Oxford, England.;Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England.4 aut |
700 | 1 | a Mulley, John F.u Bangor Univ, Sch Biol Sci, Bangor, Gwynedd, Wales.4 aut |
700 | 1 | a Ravi, Vydianathanu ASTAR, Inst Mol & Cell Biol, Comparat Genom Lab, Singapore, Singapore.4 aut |
700 | 1 | a Lee, Alison P.u ASTAR, Inst Mol & Cell Biol, Comparat Genom Lab, Singapore, Singapore.4 aut |
700 | 1 | a Nakamura, Tetsuyau Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USA.4 aut |
700 | 1 | a Chalopin, Domitilleu Ecole Normale Super Lyon, Inst Genom Fonct Lyon, F-69364 Lyon, France.;Univ Georgia, Dept Genet, Athens, GA 30602 USA.4 aut |
700 | 1 | a Fan, Shaohuau Univ Konstanz, Dept Biol, Constance, Germany.;Univ Penn, Dept Genet, Philadelphia, PA 19104 USA.4 aut |
700 | 1 | a Wcisel, Dustinu N Carolina State Univ, Dept Mol Biomed Sci, Raleigh, NC 27695 USA.;N Carolina State Univ, Ctr Comparat Med & Translat Res, Raleigh, NC 27695 USA.4 aut |
700 | 1 | a Canestro, Cristianu Univ Barcelona, Dept Genet, Barcelona, Spain.;Univ Barcelona, Inst Recerca Biodiversitat, Barcelona, Spain.4 aut |
700 | 1 | a Sydes, Jasonu Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
700 | 1 | a Beaudry, Felix E. G.u Univ Victoria, Dept Biol, POB 1700, Victoria, BC V8W 2Y2, Canada.4 aut |
700 | 1 | a Sun, Yiu Soochow Univ, Ctr Circadian Clocks, Suzhou, Peoples R China.;Soochow Univ, Coll Med, Sch Biol & Basic Med Sci, Suzhou, Peoples R China.4 aut |
700 | 1 | a Hertel, Janau Univ Leipzig, Dept Comp Sci, Bioinformat Grp, D-04109 Leipzig, Germany.;UFZ Helmholtz Ctr Environm Res, Young Investigators Grp Bioinformat & Transcript, Leipzig, Germany.4 aut |
700 | 1 | a Beam, Michael J.u Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
700 | 1 | a Fasold, Mariou Univ Leipzig, Dept Comp Sci, Bioinformat Grp, D-04109 Leipzig, Germany.;ecSeq Bioinformat, Leipzig, Germany.4 aut |
700 | 1 | a Ishiyama, Mikiou Nippon Dent Univ Coll Niigata, Dept Dent Hyg, Niigata, Japan.4 aut |
700 | 1 | a Johnson, Jeremyu MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.4 aut |
700 | 1 | a Kehr, Steffiu Univ Leipzig, Dept Comp Sci, Bioinformat Grp, D-04109 Leipzig, Germany.4 aut |
700 | 1 | a Lara, Marciau MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.4 aut |
700 | 1 | a Letaw, John H.u Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
700 | 1 | a Litman, Gary W.u Univ S Florida, Morsani Coll Med, Dept Pediat, St Petersburg, FL 33701 USA.4 aut |
700 | 1 | a Litman, Ronda T.u Univ S Florida, Morsani Coll Med, Dept Pediat, St Petersburg, FL 33701 USA.4 aut |
700 | 1 | a Mikami, Masatou Nippon Dent Univ, Sch Life Dent Niigata, Dept Microbiol, Niigata, Japan.4 aut |
700 | 1 | a Ota, Tatsuyau SOKENDAI Grad Univ Adv Studies, Dept Evolutionary Studies Biosyst, Hayama, Japan.4 aut |
700 | 1 | a Saha, Nil Ratanu Benaroya Res Inst, Mol Genet Program, Seattle, WA USA.4 aut |
700 | 1 | a Williams, Louiseu MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.4 aut |
700 | 1 | a Stadler, Peter F.u Univ Leipzig, Dept Comp Sci, Bioinformat Grp, D-04109 Leipzig, Germany.4 aut |
700 | 1 | a Wang, Hanu Soochow Univ, Ctr Circadian Clocks, Suzhou, Peoples R China.;Soochow Univ, Coll Med, Sch Biol & Basic Med Sci, Suzhou, Peoples R China.4 aut |
700 | 1 | a Taylor, John S.u Univ Victoria, Dept Biol, POB 1700, Victoria, BC V8W 2Y2, Canada.4 aut |
700 | 1 | a Fontenot, Quentonu Nicholls State Univ, Dept Biol Sci, Thibodaux, LA 70310 USA.4 aut |
700 | 1 | a Ferrara, Allyseu Nicholls State Univ, Dept Biol Sci, Thibodaux, LA 70310 USA.4 aut |
700 | 1 | a Searle, Stephen M. J.u Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.4 aut |
700 | 1 | a Aken, Bronwenu Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.;European Bioinformat Inst, European Mol Biol Lab, Wellcome Trust Genome Campus, Hinxton, England.4 aut |
700 | 1 | a Yandell, Marku Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT USA.4 aut |
700 | 1 | a Schneider, Igoru Fed Univ Para, Inst Ciencias Biol, BR-66059 Belem, Para, Brazil.4 aut |
700 | 1 | a Yoder, Jeffrey A.u N Carolina State Univ, Dept Mol Biomed Sci, Raleigh, NC 27695 USA.;N Carolina State Univ, Ctr Comparat Med & Translat Res, Raleigh, NC 27695 USA.4 aut |
700 | 1 | a Volff, Jean-Nicolasu Ecole Normale Super Lyon, Inst Genom Fonct Lyon, F-69364 Lyon, France.4 aut |
700 | 1 | a Meyer, Axelu Univ Konstanz, Dept Biol, Constance, Germany.;Univ Konstanz, Int Max Planck Res Sch Organismal Biol, Constance, Germany.4 aut |
700 | 1 | a Amemiya, Chris T.u Benaroya Res Inst, Mol Genet Program, Seattle, WA USA.4 aut |
700 | 1 | a Venkatesh, Byrappau ASTAR, Inst Mol & Cell Biol, Comparat Genom Lab, Singapore, Singapore.4 aut |
700 | 1 | a Holland, Peter W. H.u Univ Oxford, Dept Zool, Oxford, England.4 aut |
700 | 1 | a Guiguen, Yannu INRA, LPGP, UR1037, Campus Beaulieu, F-35042 Rennes, France.4 aut |
700 | 1 | a Bobe, Julienu INRA, LPGP, UR1037, Campus Beaulieu, F-35042 Rennes, France.4 aut |
700 | 1 | a Shubin, Neil H.u Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USA.4 aut |
700 | 1 | a Di Palma, Federicau MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.;Genome Anal Ctr, Vertebrate & Hlth Genom, Norwich, Norfolk, England.4 aut |
700 | 1 | a Alfoeldi, Jessicau MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.4 aut |
700 | 1 | a Lindblad-Toh, Kerstinu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard, Cambridge, MA USA.;Uppsala Univ, Dept Med Biochem & Microbiol, Sci Life Lab, Uppsala, Sweden.4 aut0 (Swepub:uu)kerli865 |
700 | 1 | a Postlethwait, John H.u Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.4 aut |
710 | 2 | a Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA.;Michigan State Univ, Dept Integrat Biol, E Lansing, MI 48824 USA.b Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USA.4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 48:4, s. 427-437q 48:4<427-437x 1061-4036x 1546-1718 |
856 | 4 | u https://doi.org/10.1038/ng.3526y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:927223/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/ng.3526.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-293022 |
856 | 4 8 | u https://doi.org/10.1038/ng.3526 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy