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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003080naa a2200397 4500
001oai:lup.lub.lu.se:208b820e-a5c9-479a-a250-cf3d2a865489
003SwePub
008160401s2006 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/3785402 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Zheng, Biying4 aut
2451 0a Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients
264 1c 2006
520 a Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. The aim of this study was to investigate the association of human papillomavirus (HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64L The study material consisted of 50 cervical intraepithelial neoplasia (CIN) cases and 50 of age and sampling-date matched controls, 100 invasive cervix cancer cases and 100 of their corresponding matched disease-free controls. Pyrosequencing (TM) was employed to genotype the CCR2-64I polymorphism. CCR5-Delta 32 was genotyped using standard PCR fragment length analysis. The frequencies of CCR2 and CCR5 genotypes from 150 patients and 150 healthy controls were representative of the general population according to the Hardy-Weinberg equilibrium analysis. Risk association was computed with conditional logistic regression analysis. HPV-positive individuals with the rare CCR5 Delta 32/Delta 32 genotype have a risk of 4.58 (CI=0.40-52.64, p-valite=0.045) compare to HPV negative group. The Delta-32 mutation on the CCR locus is imperceptibly associated with increased risk of HPV infection. In total, cervical neoplasia was not associated with genetic polymorphism of CCR2 and CCR5.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a cervical neoplasia
653 a chemokine receptor
653 a gene polymorphism
653 a pyrosequencing
7001 a Wiklund, Fredrik4 aut
7001 a Gharizadeh, Baback4 aut
7001 a Sadat, Mehdi4 aut
7001 a Gambelunghe, Giovanni4 aut
7001 a Hallmans, Goran4 aut
7001 a Dillner, Joakimu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi
7001 a Wallin, Keng-Ling4 aut
7001 a Ghaderi, Mehran4 aut
7102 a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Anticancer researchg 26:5B, s. 3669-3674q 26:5B<3669-3674x 1791-7530
8564 u http://www.iiar-anticancer.org/research/level3.php?issue=5B&volume=26&page=3669y FULLTEXT
8564 8u https://lup.lub.lu.se/record/378540

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