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Sökning: WFRF:(Wieslander Jorgen) > Circulating Anti-Gl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003449naa a2200421 4500
001oai:DiVA.org:liu-104282
003SwePub
008140214s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:128105795
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1042822 URI
0247 a https://doi.org/10.1053/j.ajkd.2013.08.0322 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1281057952 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ohlsson, Sophieu Skåne University Hospital, Sweden4 aut
2451 0a Circulating Anti-Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti-Glomerular Basement Membrane Disease
264 1b Elsevier,c 2014
338 a electronic2 rdacarrier
520 a Autoantibodies against a constituent of the glomerular basement membrane (GBM), the alpha 3-chain of type IV collagen, can cause both rapidly progressive glomerulonephritis and alveolar hemorrhage, referred to as anti-GBM disease or Goodpasture disease. Anti-GBM antibodies generally are of immunoglobulin G subclass 1 (IgG1) and can in most cases readily be detected in the circulation using enzyme-linked immunosorbent assays (ELISAs). We report 4 cases in which anti-GBM ELISA yielded negative or borderline results despite life-threatening disease. All 4 patients had positive results by IgG4 anti-GBM ELISA and all had undetectable anti-neutrophil cytoplasmic antibody. All cases were confirmed with kidney biopsy. Two of the patients showed higher signal in anti-GBM ELISA when using a nondenaturing coating buffer. All 4 were young women with severe alveolar hemorrhage and favorable renal outcome, suggesting that patients with predominance of IgG4 autoantibodies may constitute a distinct subgroup of anti-GBM disease. We conclude that patients with idiopathic alveolar hemorrhage can have anti-GBM disease detected by only IgG subclass-specific tests or kidney biopsy.
653 a Anti-glomerular basement membrane (anti-GBM); Goodpasture disease; immunoglobulin G4 (IgG4)
653 a MEDICINE
653 a MEDICIN
7001 a Herlitz, Hansu Sahlgrens University Hospital, Sweden4 aut
7001 a Lundberg, Sigridu Karolinska Institutet4 aut
7001 a Selga, Dainau Skåne University Hospital, Sweden4 aut
7001 a Molne, Johanu Sahlgrens University Hospital, Sweden4 aut
7001 a Wieslander, Jorgenu Eurodiagnost AB, Sweden4 aut
7001 a Segelmark, Mårtenu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Njurmedicinska kliniken US4 aut0 (Swepub:liu)marse71
7102 a Skåne University Hospital, Swedenb Sahlgrens University Hospital, Sweden4 org
7730 t American Journal of Kidney Diseasesd : Elsevierg 63:2, s. 289-293q 63:2<289-293x 0272-6386x 1523-6838
8564 u https://liu.diva-portal.org/smash/get/diva2:697201/FULLTEXT01.pdfx primaryx Raw objecty fulltext:preprint
8564 u http://liu.diva-portal.org/smash/get/diva2:697201/FULLTEXT01
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104282
8564 8u https://doi.org/10.1053/j.ajkd.2013.08.032
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:128105795

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