Sex specific associations in genome wide association analysis of renal cell carcinoma.

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Fältnamn	Indikatorer	Metadata
000		08281naa a2201717 4500
001		oai:DiVA.org:uu-419006
003		SwePub
008		200908s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-161383
009		oai:prod.swepub.kib.ki.se:141801221
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4190062 URI
024	7	a https://doi.org/10.1038/s41431-019-0455-92 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1613832 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1418012212 URI
040		a (SwePub)uud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Laskar, Ruhina Su International Agency for Research on Cancer (IARC), Lyon, France4 aut
245	1 0	a Sex specific associations in genome wide association analysis of renal cell carcinoma.
264		c 2019-06-23
264	1	b Springer Science and Business Media LLC,c 2019
338		a print2 rdacarrier
520		a Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Muller, David C4 aut
700	1	a Li, Peng4 aut
700	1	a Machiela, Mitchell J4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Gaborieau, Valerie4 aut
700	1	a Foll, Matthieu4 aut
700	1	a Hofmann, Jonathan N4 aut
700	1	a Colli, Leandro4 aut
700	1	a Sampson, Joshua N4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Bacq-Daian, Delphine4 aut
700	1	a Boland, Anne4 aut
700	1	a Abedi-Ardekani, Behnoush4 aut
700	1	a Durand, Geoffroy4 aut
700	1	a Le Calvez-Kelm, Florence4 aut
700	1	a Robinot, Nivonirina4 aut
700	1	a Blanche, Helene4 aut
700	1	a Prokhortchouk, Egor4 aut
700	1	a Skryabin, Konstantin G4 aut
700	1	a Burdett, Laurie4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Radojevic-Skodric, Sanja4 aut
700	1	a Savic, Slavisau Karolinska Institutet4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Mates, Dana4 aut
700	1	a Rascu, Stefan4 aut
700	1	a Mukeria, Anush4 aut
700	1	a Zaridze, David4 aut
700	1	a Bencko, Vladimir4 aut
700	1	a Cybulski, Cezary4 aut
700	1	a Fabianova, Eleonora4 aut
700	1	a Jinga, Viorel4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Navratilova, Marie4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Świątkowska, Beata4 aut
700	1	a Benhamou, Simone4 aut
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Cussenot, Olivier4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Riboli, Elio4 aut
700	1	a Overvad, Kim4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Ljungberg, Börje,d 1949-u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001
700	1	a Tumkur Sitaram, Raviprakash,d 1974-u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)tura0001
700	1	a Giles, Graham G4 aut
700	1	a Milne, Roger L4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Bruinsma, Fiona4 aut
700	1	a Fletcher, Tony4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Larsson, Susanna C4 aut
700	1	a Wolk, Alicjau Karolinska Institutet4 aut
700	1	a Banks, Rosamonde E4 aut
700	1	a Selby, Peter J4 aut
700	1	a Easton, Douglas F4 aut
700	1	a Pharoah, Paul4 aut
700	1	a Andreotti, Gabriella4 aut
700	1	a Beane Freeman, Laura E4 aut
700	1	a Koutros, Stella4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Männistö, Satu4 aut
700	1	a Weinstein, Stephanie4 aut
700	1	a Clark, Peter E4 aut
700	1	a Edwards, Todd L4 aut
700	1	a Lipworth, Loren4 aut
700	1	a Carol, Hallie4 aut
700	1	a Freedman, Matthew L4 aut
700	1	a Pomerantz, Mark M4 aut
700	1	a Cho, Eunyoung4 aut
700	1	a Kraft, Peter4 aut
700	1	a Preston, Mark A4 aut
700	1	a Wilson, Kathryn M4 aut
700	1	a Michael Gaziano, J4 aut
700	1	a Sesso, Howard D4 aut
700	1	a Black, Amanda4 aut
700	1	a Freedman, Neal D4 aut
700	1	a Huang, Wen-Yi4 aut
700	1	a Anema, John G4 aut
700	1	a Kahnoski, Richard J4 aut
700	1	a Lane, Brian R4 aut
700	1	a Noyes, Sabrina L4 aut
700	1	a Petillo, David4 aut
700	1	a Teh, Bin Tean4 aut
700	1	a Peters, Ulrike4 aut
700	1	a White, Emily4 aut
700	1	a Anderson, Garnet L4 aut
700	1	a Johnson, Lisa4 aut
700	1	a Luo, Juhua4 aut
700	1	a Chow, Wong-Ho4 aut
700	1	a Moore, Lee E4 aut
700	1	a Choueiri, Toni K4 aut
700	1	a Wood, Christopher4 aut
700	1	a Johansson, Mattias4 aut
700	1	a McKay, James D4 aut
700	1	a Brown, Kevin M4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Lathrop, Mark G4 aut
700	1	a Deleuze, Jean-Francois4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Brennan, Paul4 aut
700	1	a Chanock, Stephen J4 aut
700	1	a Purdue, Mark P4 aut
700	1	a Scelo, Ghislaineu International Agency for Research on Cancer (IARC), Lyon, France4 aut
710	2	a Karolinska Institutetb International Agency for Research on Cancer (IARC), Lyon, France4 org
773	0	t European Journal of Human Geneticsd : Springer Science and Business Media LLCg 27:10, s. 1589-1598q 27:10<1589-1598x 1018-4813x 1476-5438
856	4	u https://doi.org/10.1038/s41431-019-0455-9y Fulltext
856	4	u https://www.nature.com/articles/s41431-019-0455-9.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419006
856	4 8	u https://doi.org/10.1038/s41431-019-0455-9
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161383
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:141801221

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Av författaren/redakt...: Laskar, Ruhina S; Muller, David C; Li, Peng; Machiela, Mitche ...; Ye, Yuanqing; Gaborieau, Valer ...; visa fler...; Foll, Matthieu; Hofmann, Jonatha ...; Colli, Leandro; Sampson, Joshua ...; Wang, Zhaoming; Bacq-Daian, Delp ...; Boland, Anne; Abedi-Ardekani, ...; Durand, Geoffroy; Le Calvez-Kelm, ...; Robinot, Nivonir ...; Blanche, Helene; Prokhortchouk, E ...; Skryabin, Konsta ...; Burdett, Laurie; Yeager, Meredith; Radojevic-Skodri ...; Savic, Slavisa; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Rascu, Stefan; Mukeria, Anush; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleon ...; Jinga, Viorel; Lissowska, Jolan ...; Lubinski, Jan; Navratilova, Mar ...; Rudnai, Peter; Świątkowska, Bea ...; Benhamou, Simone; Cancel-Tassin, G ...; Cussenot, Olivie ...; Trichopoulou, An ...; Riboli, Elio; Overvad, Kim; Panico, Salvator ...; Ljungberg, Börje ...; Tumkur Sitaram, ...; Giles, Graham G; Milne, Roger L; Severi, Gianluca; Bruinsma, Fiona; Fletcher, Tony; Koppova, Kvetosl ...; Larsson, Susanna ...; Wolk, Alicja; Banks, Rosamonde ...; Selby, Peter J; Easton, Douglas ...; Pharoah, Paul; Andreotti, Gabri ...; Beane Freeman, L ...; Koutros, Stella; Albanes, Demetri ...; Männistö, Satu; Weinstein, Steph ...; Clark, Peter E; Edwards, Todd L; Lipworth, Loren; Carol, Hallie; Freedman, Matthe ...; Pomerantz, Mark ...; Cho, Eunyoung; Kraft, Peter; Preston, Mark A; Wilson, Kathryn ...; Michael Gaziano, ...; Sesso, Howard D; Black, Amanda; Freedman, Neal D; Huang, Wen-Yi; Anema, John G; Kahnoski, Richar ...; Lane, Brian R; Noyes, Sabrina L; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet ...; Johnson, Lisa; Luo, Juhua; Chow, Wong-Ho; Moore, Lee E; Choueiri, Toni K; Wood, Christophe ...; Johansson, Matti ...; McKay, James D; Brown, Kevin M; Rothman, Nathani ...; Lathrop, Mark G; Deleuze, Jean-Fr ...; Wu, Xifeng; Brennan, Paul; Chanock, Stephen ...; Purdue, Mark P; Scelo, Ghislaine; visa färre...

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