Sökning: WFRF:(Benson Mikael 1954) >
Low levels of CC16 ...
Low levels of CC16 in nasal fluid of children with birch pollen-induced rhinitis
-
- Johansson, S. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Queen Silvia Children's Hospital, Sweden
-
- Keen, Christina (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Queen Silvia Children's Hospital, Sweden
-
- Ståhl, Arne (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology,, Göteborg University, Sahlgrenska Hospital, Göteborg, Sweden
-
visa fler...
-
- Wennergren, Göran, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Queen Silvia Children's Hospital, Sweden
-
- Benson, Mikael, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Queen Silvia Children's Hospital, Sweden
-
visa färre...
-
(creator_code:org_t)
- Wiley, 2005
- 2005
- Engelska.
-
Ingår i: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 60:5, s. 638-42
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Clara cell protein 16 (CC16; secretoglobin 1A1) is an anti-inflammatory protein mainly expressed in the epithelial cells in the airways. OBJECTIVE: To compare the levels of CC16 in nasal lavage (NAL) from children with intermittent allergic rhinitis and healthy controls and to study the effect of a local steroid. METHODS: Thirty schoolchildren with birch pollen allergy and 30 healthy controls from the same schools were included in the study. The NAL fluid was collected before the season, during the birch pollen season and, for the patients, after 1 week of treatment with a local steroid. Symptom scores were obtained on every occasion. CC16 and eosinophil cationic protein (ECP) were analyzed with enzyme-linked immunosorbent assay. RESULTS: The nasal fluid levels of CC16 were significantly lower in patients than in controls, before and during pollen season. Before the season, the median CC16 concentrations were 9.1 (range 1.1-117) microg/l in patients and 25.7 (6.1-110.2) microg/l in controls. During the season, the median CC16 concentrations in nasal fluid were 12.9 (2.3-89.7) microg/l in the allergic children and 22.0 (9.5-90.1) microg/l in the healthy controls (P = 0.0005). Symptom scores, nasal fluid eosinophils and ECP were higher in patients during the season. Treatment with a local steroid did not change the CC16 levels. CONCLUSIONS: Nasal fluid CC16 levels were lower in children with birch pollen-induced allergic rhinitis than in healthy controls both before and during the pollen season. We speculate that reduction in anti-inflammatory activity by CC16 may contribute to the pathogenesis of allergic rhinitis.
Ämnesord
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adolescent
- Betula/*immunology
- Case-Control Studies
- Child
- Eosinophil Cationic Protein/metabolism
- Eosinophils/pathology
- Female
- Hay Fever/*immunology/*metabolism/pathology
- Humans
- Male
- Nasal Lavage Fluid/*chemistry/cytology/*immunology
- Pollen/*immunology
- Research Support
- Non-U.S. Gov't
- Seasons
- Uteroglobin/*metabolism
- allergic rhinitis; CC16; children; Clara cell; secretoglobin 1a1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Allergy
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas