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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007047naa a2200901 4500
001oai:lup.lub.lu.se:74bd0687-9fd0-433c-aa55-f7ae8cd24fd3
003SwePub
008240628s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/74bd0687-9fd0-433c-aa55-f7ae8cd24fd32 URI
0247 a https://doi.org/10.3390/life140202622 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Delfin, Carlu Novo Nordisk A/S4 aut
2451 0a A Federated Database for Obesity Research : An IMI-SOPHIA Study
264 1c 2024
520 a Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a bioinformatics
653 a federated database system
653 a obesity
653 a remote statistical analysis
653 a risk prediction
7001 a Dragan, Iulianu Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Kuznetsov, Dmitryu Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Tajes, Juan Fernandezu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)ju3355fe
7001 a Smit, Femkeu Maastricht University4 aut
7001 a Coral, Daniel E.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)da1078co
7001 a Farzaneh, Aliu Erasmus University Medical Center4 aut
7001 a Haugg, Andréu Boehringer Ingelheim GmbH4 aut
7001 a Hungele, Andreasu German Center for Diabetes Research4 aut
7001 a Niknejad, Anneu Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Hall, Christopheru University of Dundee4 aut
7001 a Jacobs, Daan4 aut
7001 a Marek, Dianau Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Fraser, Diane P.u University of Exeter4 aut
7001 a Thuillier, Dorothee4 aut
7001 a Ahmadizar, Faribau University Medical Center Utrecht4 aut
7001 a Mehl, Florenceu Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Pattou, Francois4 aut
7001 a Burdet, Fredericu Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Hawkes, Garethu University of Exeter4 aut
7001 a Arts, Ilja C.W.u Maastricht University4 aut
7001 a Blanch, Jordiu Catalan Institute Of Health4 aut
7001 a Van Soest, Johanu Maastricht University,Yukioka Hospital4 aut
7001 a Fernández-Real, José Manuelu Girona Biomedical Research Institute (IDIBGI),Hospital Universitari de Girona Dr. Josep Trueta,University of Girona,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)4 aut
7001 a Boehl, Juergenu Boehringer Ingelheim GmbH4 aut
7001 a Fink, Katharinau German Center for Diabetes Research4 aut
7001 a van Greevenbroek, Marleen M.J.u Maastricht University Medical Centre4 aut
7001 a Kavousi, Maryamu Erasmus University Medical Center4 aut
7001 a Minten, Michielu Maastricht University4 aut
7001 a Prinz, Nicoleu German Center for Diabetes Research4 aut
7001 a Ipsen, Nielsu Novo Nordisk A/S4 aut
7001 a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
7001 a Ramos, Rafaelu University of Girona,Erasmus University Medical Center4 aut
7001 a Holl, Reinhard W.u University of Ulm,German Center for Diabetes Research4 aut
7001 a Horban, Scottu University of Dundee4 aut
7001 a Duarte-Salles, Talitau Erasmus University Medical Center4 aut
7001 a Tran, Van Du T.u Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Raverdy, Violeta4 aut
7001 a Leal, Yennyu Hospital Universitari de Girona Dr. Josep Trueta,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),University of Girona,Girona Biomedical Research Institute (IDIBGI)4 aut
7001 a Lenart, Adamu Novo Nordisk A/S4 aut
7001 a Pearson, Ewanu University of Dundee4 aut
7001 a Sparsø, Thomasu Novo Nordisk A/S4 aut
7001 a Giordano, Giuseppe N.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-geg
7001 a Ioannidis, Vassiliosu Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Soh, Kengu Novo Nordisk A/S4 aut
7001 a Frayling, Timothy M.u University of Geneva Medical School,University of Exeter4 aut
7001 a Le Roux, Carel W.u University College Dublin4 aut
7001 a Ibberson, Marku Swiss Institute for Bioinformatics (SIB)4 aut
7102 a Novo Nordisk A/Sb Swiss Institute for Bioinformatics (SIB)4 org
7730 t Lifeg 14:2q 14:2x 0024-3019
8564 u http://dx.doi.org/10.3390/life14020262x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/74bd0687-9fd0-433c-aa55-f7ae8cd24fd3
8564 8u https://doi.org/10.3390/life14020262

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