SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Courtney M. J.)
 

Sökning: WFRF:(Courtney M. J.) > Association between...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009232naa a2201141 4500
001oai:DiVA.org:umu-142454
003SwePub
008171204s2017 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:8803677f-9b52-4741-817e-d6716d469233
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1424542 URI
0247 a https://doi.org/10.1186/s12916-017-0968-42 DOI
0247 a https://lup.lub.lu.se/record/8803677f-9b52-4741-817e-d6716d4692332 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Zheng, Ju-Shengu University of Cambridge4 aut
2451 0a Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries :b a cross-sectional analysis in the EPIC-InterAct study
264 c 2017-11-17
264 1b BioMed Central,c 2017
338 a electronic2 rdacarrier
520 a Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Saturated fatty acids
653 a Odd-chain
653 a Even-chain
653 a Very-long-chain
653 a Metabolic markers
653 a Lipids
653 a Hepatic
653 a ycaemic
653 a Inflammation
653 a Even-chain
653 a Glycaemic
653 a Hepatic
653 a Inflammation
653 a Lipids
653 a Metabolic markers
653 a Odd-chain
653 a Saturated fatty acids
653 a Very-long-chain
7001 a Sharp, Stephen J.u University of Cambridge4 aut
7001 a Imamura, Fumiakiu University of Cambridge4 aut
7001 a Koulman, Albertu MRC Human Nutrition Research,NIHR Cambridge Biomedical Research Centre4 aut
7001 a Schulze, Matthias B.u German Institute of Human Nutrition4 aut
7001 a Ye, Zhengu University of Cambridge4 aut
7001 a Griffin, Julesu University of Cambridge4 aut
7001 a Guevara, Marcelau CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)4 aut
7001 a María Huerta, Joséu Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Kröger, Janineu German Institute of Human Nutrition4 aut
7001 a Sluijs, Ivonneu University Medical Center Utrecht4 aut
7001 a Agudo, Antoniou Bellvitge University Hospital-IDIBELL4 aut
7001 a Barricarte, Aureliou CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)4 aut
7001 a Boeing, Heineru German Institute of Human Nutrition4 aut
7001 a Colorado-Yohar, Sandrau University of Antioquia4 aut
7001 a Dow, Courtneyu Stabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Dorronsoro, Mirenu Public Health Division of Gipuzkoa4 aut
7001 a Dinesen, Pia T.u Aalborg University4 aut
7001 a Fagherazzi, Guyu Stabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Franks, Paul W.u Umeå University,Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
7001 a Feskens, Edith J. M.u Wageningen University4 aut
7001 a Kühn, Tilmanu German Cancer Research Centre4 aut
7001 a Katzke, Verena Andreau German Cancer Research Centre4 aut
7001 a Key, Timothy J.u University of Oxford4 aut
7001 a Khaw, Kay-Teeu University of Cambridge4 aut
7001 a de Magistris, Maria Santucciu University of Naples Federico II4 aut
7001 a Romana Mancini, Francescau Stabilite genetique et oncogenese,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay4 aut
7001 a Molina-Portillo, Elenau University of Granada,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
7001 a Olsen, Anjau Danish Cancer Society4 aut
7001 a Overvad, Kimu Aalborg University,Aarhus University4 aut
7001 a Palli, Domenicou Cancer Research and Prevention Institute (ISPO)4 aut
7001 a Ramón Quirós, Joseu Public Health Directorate4 aut
7001 a Rolandsson, Olovu Umeå University,Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005
7001 a Ricceri, Fulviou Citta' della Salute e della Scienza Hospital-University of Turin4 aut
7001 a Spijkerman, Annemieke M. W.u National Institute for Public Health and the Environment (RIVM)4 aut
7001 a Slimani, Nadiau International Agency for Research on Cancer, World Health Organization4 aut
7001 a Tagliabue, Giovannau Istituto Nazionale dei Tumori4 aut
7001 a Tjonneland, Anneu Danish Cancer Society4 aut
7001 a Tumino, Rosariou Civic and M.P Arezzo Hospital4 aut
7001 a van der Schouw, Yvonne T.u University Medical Center Utrecht4 aut
7001 a Langenberg, Claudiau University of Cambridge4 aut
7001 a Riboli, Eliou Imperial College London4 aut
7001 a Forouhi, Nita G.u University of Cambridge4 aut
7001 a Wareham, Nicholas J.u University of Cambridge4 aut
7102 a University of Cambridgeb MRC Human Nutrition Research4 org
7730 t BMC Medicined : BioMed Centralg 15q 15x 1741-7015
8564 u https://doi.org/10.1186/s12916-017-0968-4y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1162525/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-017-0968-4
8564 u http://dx.doi.org/10.1186/s12916-017-0968-4x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142454
8564 8u https://doi.org/10.1186/s12916-017-0968-4
8564 8u https://lup.lub.lu.se/record/8803677f-9b52-4741-817e-d6716d469233

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy