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Clinical phenotypes...
Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data
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- Hedberg, P (författare)
- Karolinska Institutet
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- Valik, JK (författare)
- Karolinska Institutet
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- van der Werff, S (författare)
- Karolinska Institutet
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Tanushi, H (författare)
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- Mendez, AR (författare)
- Karolinska Institutet
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- Granath, F (författare)
- Karolinska Institutet
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- Bell, M (författare)
- Karolinska Institutet
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- Martensson, J (författare)
- Karolinska Institutet
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- Dyrdak, R (författare)
- Karolinska Institutet
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- Hertting, O (författare)
- Karolinska Institutet
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- Farnert, A (författare)
- Karolinska Institutet
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- Ternhag, A (författare)
- Karolinska Institutet
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- Naucler, P (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-07-05
- 2022
- Engelska.
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Ingår i: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 77:2, s. 154-163
- Relaterad länk:
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https://thorax.bmj.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investigate such differences in patients positive for SARS-CoV-2 compared with influenza, respiratory syncytial virus (RSV) and other respiratory viruses.MethodsWe performed a retrospective cohort study of hospitalised adults and children (≤15 years) who tested positive for SARS-CoV-2, influenza virus A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal coronaviruses, adenovirus or bocavirus in a respiratory sample at admission between 2011 and 2020.ResultsA total of 6321 adult (1721 SARS-CoV-2) and 6379 paediatric (101 SARS-CoV-2) healthcare episodes were included in the study. In adults, SARS-CoV-2 positivity was independently associated with younger age, male sex, overweight/obesity, diabetes and hypertension, tachypnoea as well as better haemodynamic measurements, white cell count, platelet count and creatinine values. Furthermore, SARS-CoV-2 was associated with higher 30-day mortality as compared with influenza (adjusted HR (aHR) 4.43, 95% CI 3.51 to 5.59), RSV (aHR 3.81, 95% CI 2.72 to 5.34) and other respiratory viruses (aHR 3.46, 95% CI 2.61 to 4.60), as well as higher 90-day mortality, ICU admission, ICU mortality and pulmonary embolism in adults. In children, patients with SARS-CoV-2 were older and had lower prevalence of chronic cardiac and respiratory diseases compared with other viruses.ConclusionsSARS-CoV-2 is associated with more severe outcomes compared with other respiratory viruses, and although associated with specific patient and clinical characteristics at admission, a substantial overlap precludes discrimination based on these characteristics.
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- art (ämneskategori)
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Thorax
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Hedberg, P
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Valik, JK
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van der Werff, S
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Tanushi, H
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Mendez, AR
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Granath, F
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visa fler...
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Bell, M
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Martensson, J
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Dyrdak, R
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Hertting, O
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Farnert, A
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Ternhag, A
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Naucler, P
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visa färre...
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Thorax
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Karolinska Institutet