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Sökning: WFRF:(Ikram Arfan M.) > CDH6 and HAGH prote...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005473naa a2200565 4500
001oai:lup.lub.lu.se:29ab12d8-2a18-4b64-9748-8ffe9edf165d
003SwePub
008200608s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:143977982
0247 a https://lup.lub.lu.se/record/29ab12d8-2a18-4b64-9748-8ffe9edf165d2 URI
0247 a https://doi.org/10.1038/s41598-020-65038-52 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1439779822 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ahmad, Shahzadu Erasmus University Medical Center4 aut
2451 0a CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers
264 c 2020-05-19
264 1b Springer Science and Business Media LLC,c 2020
520 a Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratified by APOE. Findings from the Rotterdam study were replicated in 186 AD patients of the BioFINDER study. We further evaluated the correlation of these protein biomarkers with total tau (t-tau), phosphorylated tau (p-tau) and amyloid-beta (Aβ) 42 levels in cerebrospinal fluid (CSF) in the Amsterdam Dementia Cohort (N = 441). Finally, we conducted a genome-wide association study (GWAS) to identify the genetic variants determining the blood levels of AD-associated proteins. Plasma levels of the proteins, CDH6 (β = 0.638, P = 3.33 × 10−4) and HAGH (β = 0.481, P = 7.20 × 10−4), were significantly elevated in APOE ε4 carrier AD patients. The findings in the Rotterdam Study were replicated in the BioFINDER study for both CDH6 (β = 1.365, P = 3.97 × 10−3) and HAGH proteins (β = 0.506, P = 9.31 × 10−7) when comparing cases and controls in APOE ε4 carriers. In the CSF, CDH6 levels were positively correlated with t-tau and p-tau in the total sample as well as in APOE ε4 stratum (P < 1 × 10−3). The HAGH protein was not detected in CSF. GWAS of plasma CDH6 protein levels showed significant association with a cis-regulatory locus (rs111283466, P = 1.92 × 10−9). CDH6 protein is implicated in cell adhesion and synaptogenesis while HAGH protein is related to the oxidative stress pathway. Our findings suggest that these pathways may be altered during presymptomatic AD and that CDH6 and HAGH may be new blood-based biomarkers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
7001 a Milan, Marta del Campou Vrije Universiteit Amsterdam4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
7001 a Demirkan, Ayseu Erasmus University Medical Center4 aut
7001 a Agustin, Ruizu CIBER Enfermedades Neurodegenerativas (CIBERNED),International University of Catalonia4 aut
7001 a Sáez, Maria E.4 aut
7001 a Giagtzoglou, Nikolaosu Biogen, Inc.4 aut
7001 a Cabrera-Socorro, Alfredou Janssen Pharmaceutica4 aut
7001 a Bakker, Margot H.M.u AbbVie Inc.4 aut
7001 a Ramirez, Alfredou German Center for Neurodegenerative Diseases (DZNE), Bonn,University of Cologne,University of Bonn4 aut
7001 a Hankemeier, Thomasu Leiden University4 aut
7001 a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Mattsson-Carlgren, Niklasu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-nmn
7001 a Scheltens, Philipu Vrije Universiteit Amsterdam4 aut
7001 a van der Flier, Wiesje M.u Vrije Universiteit Amsterdam4 aut
7001 a Ikram, M. Arfanu Karolinska Institutet4 aut
7001 a Malarstig, Andersu Karolinska Institutet4 aut
7001 a Teunissen, Charlotte E.u Vrije Universiteit Amsterdam4 aut
7001 a Amin, Najafu Erasmus University Medical Center4 aut
7001 a van Duijn, Cornelia M.u Erasmus University Medical Center,University of Oxford4 aut
7102 a Erasmus University Medical Centerb Vrije Universiteit Amsterdam4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 10:1q 10:1x 2045-2322
8564 u http://dx.doi.org/10.1038/s41598-020-65038-5x freey FULLTEXT
8564 u https://www.nature.com/articles/s41598-020-65038-5.pdf
8564 8u https://lup.lub.lu.se/record/29ab12d8-2a18-4b64-9748-8ffe9edf165d
8564 8u https://doi.org/10.1038/s41598-020-65038-5
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143977982

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