The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study

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The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study

Exarchou, Sofia (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Lindström, Ulf (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research

Askling, J. (författare): Karolinska Institutet

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Eriksson, J. K. (författare): Karolinska Institutet

Forsblad d'Elia, Helena, 1961 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg

Neovius, M. (författare): Karolinska Institutet

Turesson, Carl (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Kristensen, Lars Erik (författare): Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine

Jacobsson, Lennart T. H., 1954 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research

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2015-05-09
2015
Engelska.
Ingår i: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 17

Relaterad länk:: https://arthritis-re...; visa fler...; https://portal.resea... (primary) (free); http://www.ncbi.nlm....; http://dx.doi.org/10...; https://doi.org/10.1...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://lup.lub.lu.s...; https://urn.kb.se/re...; http://kipublication...; visa färre...

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Abstract Ämnesord

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Introduction: Prevalence estimates of ankylosing spondylitis vary considerably, and there are few nationwide estimates. The present study aimed to describe the national prevalence of clinically diagnosed ankylosing spondylitis in Sweden, stratified according to age, sex, geographical, and socio-economic factors, and according to subgroups with ankylosing spondylitis-related clinical manifestations and pharmacological treatment. Methods: All individuals diagnosed with ankylosing spondylitis according to the World Health Organization International Classification of Disease codes, between 1967 and 2009, were identified from the National Patient Register. Data regarding disease manifestations, patient demographics, level of education, pharmacological treatment, and geographical region were retrieved from the National Patient Register and other national registers. Results: A total of 11,030 cases with an ankylosing spondylitis diagnosis (alive, living in Sweden, and 16 to 64 years old in December 2009) were identified in the National Patient Register, giving a point prevalence of 0.18% in 2009. The prevalence was higher in northern Sweden, and lower in those with a higher level of education. Men had a higher prevalence of ankylosing spondylitis (0.23% versus 0.14%, P < 0.001), a higher frequency of anterior uveitis (25.5% versus 20.0%, P < 0.001) and were more likely to receive tumor necrosis factor inhibitors than women (15.6% versus 11.8% in 2009, P < 0.001). Women were more likely than men to have peripheral arthritis (21.7% versus 15.3%, P < 0.001), psoriasis (8.0% versus 6.9%, P = 0.03), and treatment with oral corticosteroids (14.0% versus 10.4% in 2009, P < 0.001). Conclusion: This nationwide, register-based study demonstrated a prevalence of clinically diagnosed ankylosing spondylitis of 0.18%. It revealed phenotypical and treatment differences between the sexes, as well as geographical and socio-economic differences in disease prevalence.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Nyckelord

NORTHERN NORWAY
POPULATION
SPONDYLOARTHROPATHIES
ARTHRITIS
GREECE
EPIDEMIOLOGY
MANAGEMENT
HLA-B27
SWEDEN
Rheumatology

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Av författaren/redakt...: Exarchou, Sofia; Lindström, Ulf; Askling, J.; Eriksson, J. K.; Forsblad d'Elia, ...; Neovius, M.; visa fler...; Turesson, Carl; Kristensen, Lars ...; Jacobsson, Lenna ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

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Av lärosätet: Göteborgs universitet; Lunds universitet; Umeå universitet; Karolinska Institutet

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