Sökning: WFRF:(Jerry D) >
Reduced oxygenation...
-
Edlund, JennyUppsala universitet,Institutionen för medicinsk cellbiologi
(författare)
Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
Boston, MA :Springer US,2009
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-99314
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99314URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98482URI
-
https://doi.org/10.1007/978-0-387-85998-9_31DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
By applying invasive techniques for direct measurements of oxygen tension, we have reported decreased kidney oxygenation in experimental diabetes in rats. However, the non-invasive MRI technique utilizing the BOLD effect provides several advantages with the possibility to perform repetitive measurements in the same animals and in human subjects. In this study, we applied a modified single gradient echo micro-imaging sequence to detect the BOLD effect in kidneys of diabetic rats and compared the results to normoglycemic controls. All measurements were performed on inactin-anaesthetized adult male Wistar Furth rats. Diabetes was induced by streptozotocin (45 mg/kg) 14 days prior to MRI-analysis. Sixteen T2*-weighted image records (B0=1.5 T) were performed using radiofrequency spoiled gradient echo sequence with 2.6 ms step increments of TE (TE1=12 ms), while TR (75 ms) and bandwidth per pixel (71.4 Hz) were kept constant. T2* maps were computed by mono-exponential fitting of the pixel intensities. Relaxation rates R2* (1/T2*) in cortex and outer stripe of the outer medulla were similar in both groups (cortex for controls 22.3 +/- 0.4 vs. diabetics 23.1 +/- 1.8 Hz and outer stripe of outer medulla for controls 24.9 +/- 0.4 vs. diabetics 26.4 +/- 1.8 Hz; n=4 in both groups), whereas R2* was increased in the inner stripe of the outer medulla in diabetic rats (diabetics 26.1 +/- 2.4 vs. controls 18.8 +/- 1.4 Hz; n=4, P<0.05). This study demonstrates that experimental diabetes in rats induces decreased oxygenation of the renal outer medulla. Furthermore, the proposed T2*-weighted MR micro-imaging technique is suitable for detection of regional changes in kidney oxygenation in experimental animal models.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Hansell, PeterUppsala universitet,Integrativ Fysiologi(Swepub:uu)petehans
(författare)
-
Fasching, AngelicaUppsala universitet,Integrativ Fysiologi(Swepub:uu)afa22979
(författare)
-
Liss, PerUppsala universitet,Enheten för radiologi(Swepub:uu)perliss
(författare)
-
Weis, JanUppsala universitet,Enheten för radiologi(Swepub:uu)janweis
(författare)
-
Glickson, Jerry D.
(författare)
-
Palm, FredrikUppsala universitet,Integrativ Fysiologi(Swepub:uu)fredpalm
(författare)
-
Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Advances in Experimental Medicine and BiologyBoston, MA : Springer US645, s. 199-2040065-25982214-8019
Internetlänk
Hitta via bibliotek
Till lärosätets databas