Sökning: WFRF:(Jerry D) > Reduced oxygenation...
Fältnamn | Indikatorer | Metadata |
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000 | 03625naa a2200385 4500 | |
001 | oai:DiVA.org:liu-99314 | |
003 | SwePub | |
008 | 131015s2009 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-98482 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-993142 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-984822 URI |
024 | 7 | a https://doi.org/10.1007/978-0-387-85998-9_312 DOI |
040 | a (SwePub)liud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Edlund, Jennyu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)jeedl402 |
245 | 1 0 | a Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging |
264 | 1 | a Boston, MA :b Springer US,c 2009 |
338 | a print2 rdacarrier | |
520 | a By applying invasive techniques for direct measurements of oxygen tension, we have reported decreased kidney oxygenation in experimental diabetes in rats. However, the non-invasive MRI technique utilizing the BOLD effect provides several advantages with the possibility to perform repetitive measurements in the same animals and in human subjects. In this study, we applied a modified single gradient echo micro-imaging sequence to detect the BOLD effect in kidneys of diabetic rats and compared the results to normoglycemic controls. All measurements were performed on inactin-anaesthetized adult male Wistar Furth rats. Diabetes was induced by streptozotocin (45 mg/kg) 14 days prior to MRI-analysis. Sixteen T2*-weighted image records (B0=1.5 T) were performed using radiofrequency spoiled gradient echo sequence with 2.6 ms step increments of TE (TE1=12 ms), while TR (75 ms) and bandwidth per pixel (71.4 Hz) were kept constant. T2* maps were computed by mono-exponential fitting of the pixel intensities. Relaxation rates R2* (1/T2*) in cortex and outer stripe of the outer medulla were similar in both groups (cortex for controls 22.3 +/- 0.4 vs. diabetics 23.1 +/- 1.8 Hz and outer stripe of outer medulla for controls 24.9 +/- 0.4 vs. diabetics 26.4 +/- 1.8 Hz; n=4 in both groups), whereas R2* was increased in the inner stripe of the outer medulla in diabetic rats (diabetics 26.1 +/- 2.4 vs. controls 18.8 +/- 1.4 Hz; n=4, P<0.05). This study demonstrates that experimental diabetes in rats induces decreased oxygenation of the renal outer medulla. Furthermore, the proposed T2*-weighted MR micro-imaging technique is suitable for detection of regional changes in kidney oxygenation in experimental animal models. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Hansell, Peteru Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)petehans |
700 | 1 | a Fasching, Angelicau Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)afa22979 |
700 | 1 | a Liss, Peru Uppsala universitet,Enheten för radiologi4 aut0 (Swepub:uu)perliss |
700 | 1 | a Weis, Janu Uppsala universitet,Enheten för radiologi4 aut0 (Swepub:uu)janweis |
700 | 1 | a Glickson, Jerry D.4 aut |
700 | 1 | a Palm, Fredriku Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)fredpalm |
710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
773 | 0 | t Advances in Experimental Medicine and Biologyd Boston, MA : Springer USg 645, s. 199-204q 645<199-204x 0065-2598x 2214-8019 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99314 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98482 |
856 | 4 8 | u https://doi.org/10.1007/978-0-387-85998-9_31 |
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