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Characterising the ...
Characterising the covariance pattern between lifestyle factors and structural brain measures : a multivariable replication study of two independent ageing cohorts
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- Demnitz, Naiara (författare)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark
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- Hulme, Oliver J. (författare)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark
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- Siebner, Hartwig R. (författare)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark
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- Kjaer, Michael (författare)
- Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Ebmeier, Klaus P. (författare)
- Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom
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- Boraxbekk, Carl-Johan, 1980- (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI),Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark
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- Gillan, Claire M. (författare)
- School of Psychology, Trinity College Dublin, Dublin, Ireland; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 131, s. 115-123
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Abstract
Ämnesord
Stäng
- Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Magnetic resonance imaging (MRI)
- Modifiable lifestyle factors
- Old age
- White matter hyperintensities
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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