SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Paul ES)
 

Search: WFRF:(Paul ES) > Genetic variation i...

  • van Es, Michael A (author)

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2007-12-16
  • Springer Science and Business Media LLC,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-25117
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25117URI
  • https://doi.org/10.1038/ng.2007.52DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

Added entries (persons, corporate bodies, meetings, titles ...)

  • van Vught, Paul W J (author)
  • Blauw, Hylke M (author)
  • Franke, Lude (author)
  • Saris, Christiaan G J (author)
  • Van den Bosch, Ludo (author)
  • de Jong, Sonja W (author)
  • de Jong, Vianney (author)
  • Baas, Frank (author)
  • van't Slot, Ruben (author)
  • Lemmens, Robin (author)
  • Schelhaas, Helenius J (author)
  • Birve, AnnaUmeå universitet,Neurologi (author)
  • Sleegers, Kristel (author)
  • Van Broeckhoven, Christine (author)
  • Schymick, Jennifer C (author)
  • Traynor, Bryan J (author)
  • Wokke, John H J (author)
  • Wijmenga, Cisca (author)
  • Robberecht, Wim (author)
  • Andersen, Peter MUmeå universitet,Neurologi (author)
  • Veldink, Jan H (author)
  • Ophoff, Roel A (author)
  • van den Berg, Leonard H (author)
  • Umeå universitetNeurologi (creator_code:org_t)

Related titles

  • In:Nature genetics: Springer Science and Business Media LLC40:1, s. 29-311546-17181061-4036

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view