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FältnamnIndikatorerMetadata
00009636naa a2200889 4500
001oai:DiVA.org:uu-397651
003SwePub
008191203s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3976512 URI
0247 a https://doi.org/10.1038/s41588-019-0514-82 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Malhotra, Rajeevu Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA4 aut
2451 0a HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
264 c 2019-10-28
264 1b Springer Science and Business Media LLC,c 2019
338 a print2 rdacarrier
520 a Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P < 5.0 × 10−8). No SNPs were associated with thoracic aortic calcification at the genome-wide threshold. Increased expression of HDAC9 in human aortic smooth muscle cells promoted calcification and reduced contractility, while inhibition of HDAC9 in human aortic smooth muscle cells inhibited calcification and enhanced cell contractility. In matrix Gla protein–deficient mice, a model of human vascular calcification, mice lacking HDAC9 had a 40% reduction in aortic calcification and improved survival. This translational genomic study identifies the first genetic risk locus associated with calcification of the abdominal aorta and describes a previously unknown role for HDAC9 in the development of vascular calcification.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Mauer, Andreas C.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Cardenas, Christian L. Linou Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA4 aut
7001 a Guo, Xiuqingu Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA4 aut
7001 a Yao, Jieu Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA4 aut
7001 a Zhang, Xiaolingu Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA;Boston Univ, Sch Med, Dept Med, Biomed Genet Sect, Boston, MA 02118 USA;Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA4 aut
7001 a Wunderer, Florianu Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA;Univ Hosp Frankfurt, Dept Anesthesiol Intens Care Med & Pain Therapy, Frankfurt, Germany4 aut
7001 a Smith, Albert, Vu Iceland Heart Assoc, Kopavogur, Iceland;Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA4 aut
7001 a Wong, Quennau Univ Washington, Dept Biostat, Seattle, WA 98195 USA4 aut
7001 a Pechlivanis, Sonaliu Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany4 aut
7001 a Hwang, Shih-Jenu Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA;NHLBI, Populat Sci Branch, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA4 aut
7001 a Wang, Judyu Washington Univ, Sch Med, Div Stat Genom, St Louis, MO USA4 aut
7001 a Lu, Lingyiu Wake Forest Sch Med, Winston Salem, NC 27101 USA4 aut
7001 a Nicholson, Christopher J.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Shelton, Georgiau Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Buswell, Mary D.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Barnes, Hanna J.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Sigurslid, Haakon H.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Slocum, Charlesu Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a O'Rourke, Caitlinu Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 aut
7001 a Rhee, David K.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA4 aut
7001 a Bagchi, Aranyau Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA4 aut
7001 a Nigwekar, Sagar U.u Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Dept Med, Div Nephrol, Boston, MA 02114 USA4 aut
7001 a Buys, Emmanuel S.u Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA4 aut
7001 a Campbell, Catherine Y.u Midatlant Permanente Med Grp, Rockville, MD USA4 aut
7001 a Harris, Tamarau NIA, Bethesda, MD 20892 USA4 aut
7001 a Budoff, Matthewu Harbor UCLA Med Ctr, Dept Med, Div Cardiol, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA4 aut
7001 a Criqui, Michael H.u Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA4 aut
7001 a Rotter, Jerome, Iu Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA4 aut
7001 a Johnson, Andrew D.u Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA;NHLBI, Populat Sci Branch, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA4 aut
7001 a Song, Ciu Uppsala universitet,Molekylär epidemiologi,Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA;NHLBI, Populat Sci Branch, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA4 aut0 (Swepub:uu)ciaso492
7001 a Franceschini, Norau Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA4 aut
7001 a Debette, Stephanieu Univ Bordeaux, INSERM, U1219, Bordeaux, France;Univ Hosp Bordeaux, Dept Neurol, Bordeaux, France4 aut
7001 a Hoffmann, Udou Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA4 aut
7001 a Kaelsch, Hagenu Alfried Krupp Hosp, Dept Cardiol, Essen, Germany;Witten Herdecke Univ, Witten, Germany4 aut
7001 a Noethen, Markus M.u Univ Bonn, Inst Human Genet, Bonn, Germany;Univ Bonn, Dept Genom, Life & Brain GmbH, Bonn, Germany4 aut
7001 a Sigurdsson, Sigurduru Iceland Heart Assoc, Kopavogur, Iceland4 aut
7001 a Freedman, Barry, Iu Wake Forest Sch Med, Winston Salem, NC 27101 USA4 aut
7001 a Bowden, Donald W.u Wake Forest Sch Med, Winston Salem, NC 27101 USA4 aut
7001 a Jckel, Karl-Heinzu Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany4 aut
7001 a Moebus, Susanneu Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany;Univ Hosp Essen, Ctr Urban Epidemiol, Essen, Germany4 aut
7001 a Erbel, Raimundu Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany4 aut
7001 a Feitosa, Mary F.u Washington Univ, Sch Med, Div Stat Genom, St Louis, MO USA4 aut
7001 a Gudnason, Vilmunduru Iceland Heart Assoc, Kopavogur, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland4 aut
7001 a Thanassoulis, Georgeu Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA;McGill Univ, Dept Med, Hlth Ctr, Montreal, PQ, Canada4 aut
7001 a Zapol, Warren M.u Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA4 aut
7001 a Lindsay, Mark E.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA4 aut
7001 a Bloch, Donald B.u Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA4 aut
7001 a Post, Wendy S.u Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD USA4 aut
7001 a O'Donnell, Christopher J.u Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA;Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA;US Dept Vet Affairs, Boston, MA 02203 USA4 aut
7102 a Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USAb Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA4 org
7730 t Nature Geneticsd : Springer Science and Business Media LLCg 51:11, s. 1580-+q 51:11<1580-+x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc6858575?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397651
8564 8u https://doi.org/10.1038/s41588-019-0514-8

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