WFRF:(Rothwell R)
Sökning: WFRF:(Rothwell R) > Low copy numbers of...
- 40 av 58
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03975naa a2200697 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:150871366 | |
| 003 | SwePub | |
| 008 | 240913s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1508713662 URI |
| 024 | 7 | a https://doi.org/10.1136/ard-2022-2229352 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhou, D4 aut |
| 245 | 1 0 | a Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies |
| 264 | c 2022-09-28 | |
| 264 | 1 | b BMJ,c 2023 |
| 520 | a Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle fibres, chronic weakness and fatigue. While complement-mediated destruction of capillary endothelia is implicated in paediatric and adult dermatomyositis, the complex diversity of complementC4in IIM pathology was unknown.MethodsWe elucidated the gene copy number (GCN) variations of totalC4,C4AandC4B, longandshort genesin 1644 Caucasian patients with IIM, plus 3526 matched healthy controls using real-time PCR or Southern blot analyses. Plasma complement levels were determined by single radial immunodiffusion.ResultsThe large study populations helped establish the distribution patterns of variousC4GCN groups. Low GCNs ofC4T(C4T=2+3) andC4Adeficiency (C4A=0+1) were strongly correlated with increased risk of IIM with OR equalled to 2.58 (2.28–2.91), p=5.0×10−53forC4T, and 2.82 (2.48–3.21), p=7.0×10−57forC4Adeficiency. Contingency and regression analyses showed that among patients withC4Adeficiency, the presence ofHLA-DR3became insignificant as a risk factor in IIM except for inclusion body myositis (IBM), by which 98.2% hadHLA-DR3with an OR of 11.02 (1.44–84.4). Intragroup analyses of patients with IIM for C4 protein levels and IIM-related autoantibodies showed that those with anti-Jo-1 or with anti-PM/Scl had significantly lower C4 plasma concentrations than those without these autoantibodies.ConclusionsC4Adeficiency is relevant in dermatomyositis,HLA-DRB1*03is important in IBM and bothC4Adeficiency andHLA-DRB1*03contribute interactively to risk of polymyositis. | |
| 700 | 1 | a King, EH4 aut |
| 700 | 1 | a Rothwell, S4 aut |
| 700 | 1 | a Krystufkova, O4 aut |
| 700 | 1 | a Notarnicola, Au Karolinska Institutet4 aut |
| 700 | 1 | a Coss, S4 aut |
| 700 | 1 | a Abdul-Aziz, R4 aut |
| 700 | 1 | a Miller, KE4 aut |
| 700 | 1 | a Dang, A4 aut |
| 700 | 1 | a Yu, GR4 aut |
| 700 | 1 | a Drew, J4 aut |
| 700 | 1 | a Lundstrom, E4 aut |
| 700 | 1 | a Pachman, LM4 aut |
| 700 | 1 | a Mamyrova, G4 aut |
| 700 | 1 | a Curiel, R4 aut |
| 700 | 1 | a De Paepe, B4 aut |
| 700 | 1 | a De Bleecker, JL4 aut |
| 700 | 1 | a Payton, A4 aut |
| 700 | 1 | a Ollier, W4 aut |
| 700 | 1 | a O'Hanlon, TP4 aut |
| 700 | 1 | a Targoff, IN4 aut |
| 700 | 1 | a Flegel, WA4 aut |
| 700 | 1 | a Sivaraman, V4 aut |
| 700 | 1 | a Oberle, E4 aut |
| 700 | 1 | a Akoghlanian, S4 aut |
| 700 | 1 | a Driest, K4 aut |
| 700 | 1 | a Spencer, CH4 aut |
| 700 | 1 | a Wu, YL4 aut |
| 700 | 1 | a Nagaraja, HN4 aut |
| 700 | 1 | a Ardoin, SP4 aut |
| 700 | 1 | a Chinoy, H4 aut |
| 700 | 1 | a Rider, LG4 aut |
| 700 | 1 | a Miller, FW4 aut |
| 700 | 1 | a Lundberg, IEu Karolinska Institutet4 aut |
| 700 | 1 | a Padyukov, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Vencovsky, J4 aut |
| 700 | 1 | a Lamb, JA4 aut |
| 700 | 1 | a Yu, CY4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Annals of the rheumatic diseasesd : BMJg 82:2, s. 235-245q 82:2<235-245x 1468-2060x 0003-4967 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150871366 |
| 856 | 4 8 | u https://doi.org/10.1136/ard-2022-222935 |
Hitta via bibliotek
- Annals of the rheumatic diseases (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 40 av 58
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Zhou, D
- King, EH
- Rothwell, S
- Krystufkova, O
- Notarnicola, A
- Coss, S
- visa fler...
- Abdul-Aziz, R
- Miller, KE
- Dang, A
- Yu, GR
- Drew, J
- Lundstrom, E
- Pachman, LM
- Mamyrova, G
- Curiel, R
- De Paepe, B
- De Bleecker, JL
- Payton, A
- Ollier, W
- O'Hanlon, TP
- Targoff, IN
- Flegel, WA
- Sivaraman, V
- Oberle, E
- Akoghlanian, S
- Driest, K
- Spencer, CH
- Wu, YL
- Nagaraja, HN
- Ardoin, SP
- Chinoy, H
- Rider, LG
- Miller, FW
- Lundberg, IE
- Padyukov, L
- Vencovsky, J
- Lamb, JA
- Yu, CY
- visa färre...
- Artiklar i publikationen
- Annals of the rh ...
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
