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Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial functions
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- Bove, Mogens, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för öron, näs- och halssjukdomar,Institute of Selected Clinical Sciences, Department of Otolaryngology
- Vieth, M. (author)
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- Casselbrant, Anna, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 2005
- 2005
- English.
- In: Dig Dis Sci. - : Springer Science and Business Media LLC. - 0163-2116 .- 1573-2568. ; 50:4, s. 640-8
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- To evaluate the effect of esophageal acid exposure on epithelial function, transmucosal potential, histopathological markers of acute tissue damage, and local nitric oxide production were examined in healthy volunteers treated with proton pump inhibitors (group I), patients with treated reflux disease (group II), and patients with untreated erosive reflux disease (group III). The participants were randomized to esophageal perfusion with either saline or HCl. Denominators of acute acid exposure were balloon cells in superficial layers and superficial densification. The nitric oxide concentrations in groups I to III increased from < 1, 10.0+/-10.0, and 20.6+/-19.9 ppb, respectively, to 300+/-80, 1360+/-1080, and 920+/-700 ppb after HCl infusion (P < 0.001). Inducible nitric oxide synthase was consistently expressed in the epithelium. Blood flow was lower among reflux patients but did not correlate with acid exposure or nitric oxide. Nitric oxide is formed following acid perfusion and predominantly in gastroesophageal reflux disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Adult
- Aged
- Blotting
- Western
- Electrophysiology
- Esophagus/blood supply/*drug effects/pathology/*physiopathology
- Female
- Gastroesophageal Reflux/drug therapy/pathology/*physiopathology
- Humans
- Hydrochloric Acid/*diagnostic use
- Immunohistochemistry
- Male
- Middle Aged
- Mucous Membrane/blood supply/*drug effects/pathology/*physiopathology
- Nitric Oxide/*biosynthesis
- Nitric Oxide Synthase/metabolism
- Nitric Oxide Synthase Type II
- Polymerase Chain Reaction
- Proton Pumps/antagonists & inhibitors
- Regional Blood Flow/drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Karolinska Institutet
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