Sökning: WFRF:(Vieth M.) > Acid challenge to t...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04543naa a2200601 4500 | |
001 | oai:gup.ub.gu.se/52303 | |
003 | SwePub | |
008 | 240528s2005 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1938406 | |
024 | 7 | a https://gup.ub.gu.se/publication/523032 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19384062 URI |
024 | 7 | a https://doi.org/10.1007/s10620-005-2550-82 DOI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bove, Mogens,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för öron, näs- och halssjukdomar,Institute of Selected Clinical Sciences, Department of Otolaryngology4 aut |
245 | 1 0 | a Acid challenge to the esophageal mucosa: effects on local nitric oxide formation and its relation to epithelial functions |
264 | 1 | b Springer Science and Business Media LLC,c 2005 |
520 | a To evaluate the effect of esophageal acid exposure on epithelial function, transmucosal potential, histopathological markers of acute tissue damage, and local nitric oxide production were examined in healthy volunteers treated with proton pump inhibitors (group I), patients with treated reflux disease (group II), and patients with untreated erosive reflux disease (group III). The participants were randomized to esophageal perfusion with either saline or HCl. Denominators of acute acid exposure were balloon cells in superficial layers and superficial densification. The nitric oxide concentrations in groups I to III increased from < 1, 10.0+/-10.0, and 20.6+/-19.9 ppb, respectively, to 300+/-80, 1360+/-1080, and 920+/-700 ppb after HCl infusion (P < 0.001). Inducible nitric oxide synthase was consistently expressed in the epithelium. Blood flow was lower among reflux patients but did not correlate with acid exposure or nitric oxide. Nitric oxide is formed following acid perfusion and predominantly in gastroesophageal reflux disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
653 | a Adult | |
653 | a Aged | |
653 | a Blotting | |
653 | a Western | |
653 | a Electrophysiology | |
653 | a Esophagus/blood supply/*drug effects/pathology/*physiopathology | |
653 | a Female | |
653 | a Gastroesophageal Reflux/drug therapy/pathology/*physiopathology | |
653 | a Humans | |
653 | a Hydrochloric Acid/*diagnostic use | |
653 | a Immunohistochemistry | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Mucous Membrane/blood supply/*drug effects/pathology/*physiopathology | |
653 | a Nitric Oxide/*biosynthesis | |
653 | a Nitric Oxide Synthase/metabolism | |
653 | a Nitric Oxide Synthase Type II | |
653 | a Polymerase Chain Reaction | |
653 | a Proton Pumps/antagonists & inhibitors | |
653 | a Regional Blood Flow/drug effects | |
700 | 1 | a Vieth, M.4 aut |
700 | 1 | a Casselbrant, Anna,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research4 aut0 (Swepub:gu)xcassa |
700 | 1 | a Ny, Lars,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology4 aut0 (Swepub:gu)xnylai |
700 | 1 | a Lundell, L.u Karolinska Institutet4 aut |
700 | 1 | a Ruth, Magnus,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institutionen för särskilda specialiteter, Avdelningen för öron, näs- och halssjukdomar,Institute of Surgical Sciences,Institute of Selected Clinical Sciences, Department of Otolaryngology4 aut0 (Swepub:gu)xrutma |
710 | 2 | a Göteborgs universitetb Institutionen för särskilda specialiteter, Avdelningen för öron, näs- och halssjukdomar4 org |
773 | 0 | t Dig Dis Scid : Springer Science and Business Media LLCg 50:4, s. 640-8q 50:4<640-8x 0163-2116x 1573-2568 |
856 | 4 8 | u https://gup.ub.gu.se/publication/52303 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938406 |
856 | 4 8 | u https://doi.org/10.1007/s10620-005-2550-8 |
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