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Sökning: WFRF:(Wåhlin Anders) > (2010-2019) > C957T-mediated Vari...

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FältnamnIndikatorerMetadata
00004787naa a2200505 4500
001oai:DiVA.org:su-165644
003SwePub
008190208s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-155630
009oai:prod.swepub.kib.ki.se:139902107
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1656442 URI
0247 a https://doi.org/10.1162/jocn_a_013542 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1556302 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1399021072 URI
040 a (SwePub)sud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Karalija, Nina,d 1984-u Umeå universitet,Diagnostisk radiologi4 aut0 (Swepub:umu)nine0001
2451 0a C957T-mediated Variation in Ligand Affinity Affects the Association between C-11-raclopride Binding Potential and Cognition
264 1b MIT Press,c 2019
338 a print2 rdacarrier
520 a The dopamine (DA) system plays an important role in cognition. Accordingly, normal variation in DA genes has been found to predict individual differences in cognitive performance. However, little is known of the impact of genetic differences on the link between empirical indicators of the DA system and cognition in humans. The present work used PET with C-11-raclopride to assess DA D2-receptor binding potential (BP) and links to episodic memory, working memory, and perceptual speed in 179 healthy adults aged 64-68 years. Previously, the T-allele of a DA D2-receptor single-nucleotide polymorphism, C957T, was associated with increased apparent affinity of C-11-raclopride, giving rise to higher BP values despite similar receptor density values between allelic groups. Consequently, we hypothesized that C-11-raclopride BP measures inflated by affinity rather than D2-receptor density in T-allele carriers would not be predictive of DA integrity and therefore prevent finding an association between C-11-raclopride BP and cognitive performance. In accordance with previous findings, we show that C-11-raclopride BP was increased in T-homozygotes. Importantly, C-11-raclopride BP was only associated with cognitive performance in groups with low or average ligand affinity (C-allele carriers of C957T, n = 124), but not in the high-affinity group (T-homozygotes, n = 55). The strongest C-11-raclopride BP-cognition associations and the highest level of performance were found in C-homozygotes. These findings show that genetic differences modulate the link between BP and cognition and thus have important implications for the interpretation of DA assessments with PET and C-11-raclopride in multiple disciplines ranging from cognitive neuroscience to psychiatry and neurology.
650 7a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650 7a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Papenberg, Goranu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
7001 a Wåhlin, Andersu Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)arswan02
7001 a Johansson, Jarkkou Umeå universitet4 aut0 (Swepub:umu)jajo0061
7001 a Andersson, Micaelu Umeå universitet4 aut0 (Swepub:umu)mian0001
7001 a Axelsson, Jan,d 1966-u Umeå universitet4 aut0 (Swepub:umu)jaax0004
7001 a Riklund, Katrineu Umeå universitet4 aut0 (Swepub:umu)kaah0001
7001 a Lövdén, Martinu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
7001 a Lindenberger, Ulman4 aut
7001 a Bäckman, Larsu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
7001 a Nyberg, Lars,d 1966-u Umeå universitet4 aut0 (Swepub:umu)lany0001
7102 a Umeå universitetb Diagnostisk radiologi4 org
7730 t Journal of cognitive neuroscienced : MIT Pressg 31:2, s. 314-325q 31:2<314-325x 0898-929Xx 1530-8898
8564 u https://pure.mpg.de/pubman/item/item_3037579_4/component/file_3047487/id10008121.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-165644
8564 8u https://doi.org/10.1162/jocn_a_01354
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155630
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139902107

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