A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

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Fältnamn	Indikatorer	Metadata
000		06447naa a2201417 4500
001		oai:DiVA.org:umu-51644
003		SwePub
008		120131s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-516442 URI
024	7	a https://doi.org/10.1093/hmg/ddr4792 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wu, Xifeng4 aut
245	1 0	a A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23
264		c 2011-10-18
264	1	b Oxford University Press (OUP),c 2012
338		a print2 rdacarrier
520		a Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. We identified two common variants in linkage disequilibrium, rs718314 and rs1049380 (r(2) = 0.64, D' = 0.84), in the inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 x 10(-10) and P = 6.07 x 10(-9), respectively, in meta-analysis) with an allelic odds ratio of 1.19 [95% confidence interval (CI): 1.13-1.26] for rs718314 and 1.18 (95% CI: 1.12-1.25) for rs1049380. It has been recently identified that rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Scelo, Ghislaine4 aut
700	1	a Purdue, Mark P.4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Johansson, Mattiasu International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97
700	1	a Ye, Yuanqing4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Zelenika, Diana4 aut
700	1	a Moore, Lee E.4 aut
700	1	a Wood, Christopher G.4 aut
700	1	a Prokhortchouk, Egor4 aut
700	1	a Gaborieau, Valerie4 aut
700	1	a Jacobs, Kevin B.4 aut
700	1	a Chow, Wong-Ho4 aut
700	1	a Toro, Jorge R.4 aut
700	1	a Zaridze, David4 aut
700	1	a Lin, Jie4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Trubicka, Joanna4 aut
700	1	a Szeszenia-Dabrowska, Neonilia4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Fabianova, Eleonora4 aut
700	1	a Mates, Dana4 aut
700	1	a Jinga, Viorel4 aut
700	1	a Bencko, Vladimir4 aut
700	1	a Slamova, Alena4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Navratilova, Marie4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Boffetta, Paolo4 aut
700	1	a Colt, Joanne S.4 aut
700	1	a Davis, Faith G.4 aut
700	1	a Schwartz, Kendra L.4 aut
700	1	a Banks, Rosamonde E.4 aut
700	1	a Selby, Peter J.4 aut
700	1	a Harnden, Patricia4 aut
700	1	a Berg, Christine D.4 aut
700	1	a Hsing, Ann W.4 aut
700	1	a Grubb, Robert L., III4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Palli, Domenico4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Krogh, Vittorio4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Ramon Quiros, Jose4 aut
700	1	a Sanchez, Maria-Jose4 aut
700	1	a Navarro, Carmen4 aut
700	1	a Ardanaz, Eva4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Allen, Naomi E.4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Peeters, Petra H. M.4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Linseisen, Jakob4 aut
700	1	a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001
700	1	a Overvad, Kim4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Romieu, Isabelle4 aut
700	1	a Riboli, Elio4 aut
700	1	a Stevens, Victoria L.4 aut
700	1	a Thun, Michael J.4 aut
700	1	a Diver, W. Ryan4 aut
700	1	a Gapstur, Susan M.4 aut
700	1	a Pharoah, Paul D.4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Vatten, Lars4 aut
700	1	a Hveem, Kristian4 aut
700	1	a Fletcher, Tony4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Cussenot, Olivier4 aut
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Benhamou, Simone4 aut
700	1	a Hildebrandt, Michelle A.4 aut
700	1	a Pu, Xia4 aut
700	1	a Foglio, Mario4 aut
700	1	a Lechner, Doris4 aut
700	1	a Hutchinson, Amy4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Fraumeni, Joseph F., Jr.4 aut
700	1	a Lathrop, Mark4 aut
700	1	a Skryabin, Konstantin G.4 aut
700	1	a McKay, James D.4 aut
700	1	a Gu, Jian4 aut
700	1	a Brennan, Paul4 aut
700	1	a Chanock, Stephen J.4 aut
710	2	a International Agency for Research on Cancer (IARC), Lyon, Franceb Urologi och andrologi4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 21:2, s. 456-462q 21:2<456-462x 0964-6906x 1460-2083
856	4	u https://academic.oup.com/hmg/article-pdf/21/2/456/17257430/ddr479.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51644
856	4 8	u https://doi.org/10.1093/hmg/ddr479

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Av författaren/redakt...: Wu, Xifeng; Scelo, Ghislaine; Purdue, Mark P.; Rothman, Nathani ...; Johansson, Matti ...; Ye, Yuanqing; visa fler...; Wang, Zhaoming; Zelenika, Diana; Moore, Lee E.; Wood, Christophe ...; Prokhortchouk, E ...; Gaborieau, Valer ...; Jacobs, Kevin B.; Chow, Wong-Ho; Toro, Jorge R.; Zaridze, David; Lin, Jie; Lubinski, Jan; Trubicka, Joanna; Szeszenia-Dabrow ...; Lissowska, Jolan ...; Rudnai, Peter; Fabianova, Eleon ...; Mates, Dana; Jinga, Viorel; Bencko, Vladimir; Slamova, Alena; Holcatova, Ivana; Navratilova, Mar ...; Janout, Vladimir; Boffetta, Paolo; Colt, Joanne S.; Davis, Faith G.; Schwartz, Kendra ...; Banks, Rosamonde ...; Selby, Peter J.; Harnden, Patrici ...; Berg, Christine ...; Hsing, Ann W.; Grubb, Robert L. ...; Boeing, Heiner; Vineis, Paolo; Clavel-Chapelon, ...; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvator ...; Duell, Eric J.; Ramon Quiros, Jo ...; Sanchez, Maria-J ...; Navarro, Carmen; Ardanaz, Eva; Dorronsoro, Mire ...; Khaw, Kay-Tee; Allen, Naomi E.; Bueno-de-Mesquit ...; Peeters, Petra H ...; Trichopoulos, Di ...; Linseisen, Jakob; Ljungberg, Börje; Overvad, Kim; Tjonneland, Anne; Romieu, Isabelle; Riboli, Elio; Stevens, Victori ...; Thun, Michael J.; Diver, W. Ryan; Gapstur, Susan M ...; Pharoah, Paul D.; Easton, Douglas ...; Albanes, Demetri ...; Virtamo, Jarmo; Vatten, Lars; Hveem, Kristian; Fletcher, Tony; Koppova, Kvetosl ...; Cussenot, Olivie ...; Cancel-Tassin, G ...; Benhamou, Simone; Hildebrandt, Mic ...; Pu, Xia; Foglio, Mario; Lechner, Doris; Hutchinson, Amy; Yeager, Meredith; Fraumeni, Joseph ...; Lathrop, Mark; Skryabin, Konsta ...; McKay, James D.; Gu, Jian; Brennan, Paul; Chanock, Stephen ...; visa färre...

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Av lärosätet: Umeå universitet

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