A Mathematical Model for Interpretable Clinical Decision Support with Applications in Gynecology

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Fältnamn	Indikatorer	Metadata
000		04316naa a2200433 4500
001		oai:lup.lub.lu.se:949cbfbb-09f9-4b50-9086-161d3b305880
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/29117092 URI
024	7	a https://doi.org/10.1371/journal.pone.00343122 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Van Belle, Vanya M. C. A.4 aut
245	1 0	a A Mathematical Model for Interpretable Clinical Decision Support with Applications in Gynecology
264		c 2012-03-29
264	1	b Public Library of Science (PLoS),c 2012
338		a electronic2 rdacarrier
520		a Background: Over time, methods for the development of clinical decision support (CDS) systems have evolved from interpretable and easy-to-use scoring systems to very complex and non-interpretable mathematical models. In order to accomplish effective decision support, CDS systems should provide information on how the model arrives at a certain decision. To address the issue of incompatibility between performance, interpretability and applicability of CDS systems, this paper proposes an innovative model structure, automatically leading to interpretable and easily applicable models. The resulting models can be used to guide clinicians when deciding upon the appropriate treatment, estimating patient-specific risks and to improve communication with patients. Methods and Findings: We propose the interval coded scoring (ICS) system, which imposes that the effect of each variable on the estimated risk is constant within consecutive intervals. The number and position of the intervals are automatically obtained by solving an optimization problem, which additionally performs variable selection. The resulting model can be visualised by means of appealing scoring tables and color bars. ICS models can be used within software packages, in smartphone applications, or on paper, which is particularly useful for bedside medicine and home-monitoring. The ICS approach is illustrated on two gynecological problems: diagnosis of malignancy of ovarian tumors using a dataset containing 3,511 patients, and prediction of first trimester viability of pregnancies using a dataset of 1,435 women. Comparison of the performance of the ICS approach with a range of prediction models proposed in the literature illustrates the ability of ICS to combine optimal performance with the interpretability of simple scoring systems. Conclusions: The ICS approach can improve patient-clinician communication and will provide additional insights in the importance and influence of available variables. Future challenges include extensions of the proposed methodology towards automated detection of interaction effects, multi-class decision support systems, prognosis and high-dimensional data.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
700	1	a Van Calster, Ben4 aut
700	1	a Timmerman, Dirk4 aut
700	1	a Bourne, Tom4 aut
700	1	a Bottomley, Cecilia4 aut
700	1	a Valentin, Lilu Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups4 aut0 (Swepub:lu)obst-lva
700	1	a Neven, Patrick4 aut
700	1	a Van Huffel, Sabine4 aut
700	1	a Suykens, Johan A. K.4 aut
700	1	a Boyd, Stephen4 aut
710	2	a Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostikb Forskargrupper vid Lunds universitet4 org
773	0	t PLoS ONEd : Public Library of Science (PLoS)g 7:3q 7:3x 1932-6203
856	4	u https://portal.research.lu.se/files/3810985/3350510.pdfx primaryx freey FULLTEXT
856	4	u http://dx.doi.org/10.1371/journal.pone.0034312x freey FULLTEXT
856	4	u https://doi.org/10.1371/journal.pone.0034312
856	4 8	u https://lup.lub.lu.se/record/2911709
856	4 8	u https://doi.org/10.1371/journal.pone.0034312

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Av författaren/redakt...: Van Belle, Vanya ...; Van Calster, Ben; Timmerman, Dirk; Bourne, Tom; Bottomley, Cecil ...; Valentin, Lil; visa fler...; Neven, Patrick; Van Huffel, Sabi ...; Suykens, Johan A ...; Boyd, Stephen; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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Av lärosätet: Lunds universitet

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