Heritability of retinal vascular fractals : A twin study

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Fältnamn	Indikatorer	Metadata
000		04306naa a2200469 4500
001		oai:lup.lub.lu.se:a844dbbb-c88e-4204-afd9-05d77e52afdf
003		SwePub
008		170904s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/a844dbbb-c88e-4204-afd9-05d77e52afdf2 URI
024	7	a https://doi.org/10.1167/iovs.17-220722 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Vergmann, Anna Stageu University of Southern Denmark,Odense University Hospital4 aut
245	1 0	a Heritability of retinal vascular fractals : A twin study
264	1	b Association for Research in Vision and Ophthalmology (ARVO),c 2017
300		a 6 s.
520		a PURPOSE. To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. METHODS. This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50º, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer’s formula and quantitative genetic models were used to determine the genetic component of variation. RESULTS. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined. CONCLUSIONS. In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng
653		a Dizogotic
653		a Heredity
653		a Monozygotic
653		a Retinal vascular fractal dimension
653		a Twin
700	1	a Broe, Rebeccau Odense University Hospital,University of Southern Denmark4 aut
700	1	a Kessel, Lineu Copenhagen University Hospital,University of Copenhagen4 aut
700	1	a Hougaard, Jesper Lethu Lund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups4 aut0 (Swepub:lu)ofta-jho
700	1	a Möller Christensen, Sören, Sörenu University of Southern Denmark,Odense University Hospital4 aut
700	1	a Kyvik, Kirsten Ohmu Odense University Hospital,University of Southern Denmark4 aut
700	1	a Larsen, Michaelu University of Copenhagen,Copenhagen University Hospital4 aut
700	1	a Munch, Inger Christineu University of Copenhagen,Zealand University Hospital4 aut
700	1	a Grauslund, Jakobu University of Southern Denmark,Odense University Hospital4 aut
710	2	a University of Southern Denmarkb Odense University Hospital4 org
773	0	t Investigative Ophthalmology and Visual Scienced : Association for Research in Vision and Ophthalmology (ARVO)g 58:10, s. 3997-4002q 58:10<3997-4002x 0146-0404
773	0	t Investigative Opthalmology & Visual Scienced : Association for Research in Vision and Ophthalmology (ARVO)g 58:10, s. 3997-4002q 58:10<3997-4002x 1552-5783
856	4	u http://dx.doi.org/10.1167/iovs.17-22072x freey FULLTEXT
856	4	u https://doi.org/10.1167/iovs.17-22072
856	4 8	u https://lup.lub.lu.se/record/a844dbbb-c88e-4204-afd9-05d77e52afdf
856	4 8	u https://doi.org/10.1167/iovs.17-22072

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Av författaren/redakt...: Vergmann, Anna S ...; Broe, Rebecca; Kessel, Line; Hougaard, Jesper ...; Möller Christens ...; Kyvik, Kirsten O ...; visa fler...; Larsen, Michael; Munch, Inger Chr ...; Grauslund, Jakob; visa färre...

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