WFRF:(Jacques T)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05203naa a2200949 4500 | |
| 001 | oai:DiVA.org:uu-154280 | |
| 003 | SwePub | |
| 008 | 110530s2011 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:122562197 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1542802 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pgen.10013782 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1225621972 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Smedby, Karin E.u Karolinska Institutet4 aut |
| 245 | 1 0 | a GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma |
| 264 | c 2011-04-21 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (ORcombined = 0.64, P-combined= 2x10(-21)) located 962 bp away from rs10484561 (r(2)< 0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012: ORadjusted = 0.70, P-adjusted= 4x10(-12); rs10484561: ORadjusted = 1.64, P-adjusted= 5x10(-15)). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (ORcombined = 1.36, P-combined = 1.4x10(-7)). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Foo, Jia Nee4 aut |
| 700 | 1 | a Skibola, Christine F.4 aut |
| 700 | 1 | a Darabi, Hatefu Karolinska Institutet4 aut |
| 700 | 1 | a Conde, Lucia4 aut |
| 700 | 1 | a Hjalgrim, Henriku Karolinska Institutet4 aut |
| 700 | 1 | a Kumar, Vikrant4 aut |
| 700 | 1 | a Chang, Ellen T.4 aut |
| 700 | 1 | a Rothman, Nathaniel4 aut |
| 700 | 1 | a Cerhan, James R.4 aut |
| 700 | 1 | a Brooks-Wilson, Angela R.4 aut |
| 700 | 1 | a Rehnberg, Emil4 aut |
| 700 | 1 | a Irwan, Ishak D.4 aut |
| 700 | 1 | a Ryder, Lars P.u Karolinska Institutet4 aut |
| 700 | 1 | a Brown, Peter N.4 aut |
| 700 | 1 | a Bracci, Paige M.4 aut |
| 700 | 1 | a Agana, Luz4 aut |
| 700 | 1 | a Riby, Jacques4 aut |
| 700 | 1 | a Cozen, Wendy4 aut |
| 700 | 1 | a Davis, Scott4 aut |
| 700 | 1 | a Hartge, Patricia4 aut |
| 700 | 1 | a Morton, Lindsay M.4 aut |
| 700 | 1 | a Severson, Richard K.4 aut |
| 700 | 1 | a Wang, Sophia S.4 aut |
| 700 | 1 | a Slager, Susan L.4 aut |
| 700 | 1 | a Fredericksen, Zachary S.4 aut |
| 700 | 1 | a Novak, Anne J.4 aut |
| 700 | 1 | a Kay, Neil E.4 aut |
| 700 | 1 | a Habermann, Thomas M.4 aut |
| 700 | 1 | a Armstrong, Bruce4 aut |
| 700 | 1 | a Kricker, Anne4 aut |
| 700 | 1 | a Milliken, Sam4 aut |
| 700 | 1 | a Purdue, Mark P.4 aut |
| 700 | 1 | a Vajdic, Claire M.4 aut |
| 700 | 1 | a Boyle, Peter4 aut |
| 700 | 1 | a Lan, Qing4 aut |
| 700 | 1 | a Zahm, Shelia H.4 aut |
| 700 | 1 | a Zhang, Yawei4 aut |
| 700 | 1 | a Zheng, Tongzhang4 aut |
| 700 | 1 | a Leach, Stephen4 aut |
| 700 | 1 | a Spinelli, John J.4 aut |
| 700 | 1 | a Smith, Martyn T.4 aut |
| 700 | 1 | a Chanock, Stephen J.4 aut |
| 700 | 1 | a Padyukov, Leonid4 aut |
| 700 | 1 | a Alfredsson, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Klareskog, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Glimelius, Bengtu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)bengglim |
| 700 | 1 | a Melbye, Mads4 aut |
| 700 | 1 | a Liu, Edison T.4 aut |
| 700 | 1 | a Adami, Hans-Olov4 aut |
| 700 | 1 | a Humphreys, Keithu Karolinska Institutet4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 710 | 2 | a Karolinska Institutetb Enheten för onkologi4 org |
| 773 | 0 | t PLoS Geneticsd : Public Library of Science (PLoS)g 7:4, s. e1001378-q 7:4<e1001378-x 1553-7390x 1553-7404 |
| 856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001378&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154280 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1001378 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122562197 |
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