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  • Sundelöf, JohanUppsala universitet,Geriatrik (author)

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-132167
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132167URI
  • https://doi.org/10.3233/JAD-2010-101023DOI
  • https://lup.lub.lu.se/record/1814776URI
  • https://gup.ub.gu.se/publication/135826URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121840931URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cathepsin B is suggested to be involved in amyloid-β (Aβ) processing and Alzheimer's disease (AD). Studies of cathepsin B levels in plasma and cerebrospinal fluid (CSF) have not been previously performed. We examined cathepsin B levels in plasma and CSF samples in persons with AD, mild cognitive impairment (MCI), and healthy controls in order to test the hypothesis that cathepsin B levels can discriminate persons with AD or MCI from healthy controls. Cathepsin B, Cystatin C, Aβ1-40 and Aβ1-42, total tau, phosphorylated tau, and albumin levels in plasma and CSF were analyzed by ELISA (Cathepsin B) turbidimetry (cystatin C), xMAP Luminex technology (Aβ1-40 and Aβ1-42 and tau), and Cobas C501 analyzer (albumin) in persons with AD (n=101), MCI (n=84), and healthy control subjects (n=28). Plasma cathepsin B levels were higher in persons with AD compared to healthy controls, both in unadjusted models and in multivariable models adjusting for age, gender, APOE genotype, cystatin C, and albumin levels: Odds ratio (OR) for AD per 1 SD of plasma cathepsin B; 2.04, 95% confidence interval (CI); 1.01-4.14, p= 0.05. There was no difference between diagnostic groups in cathepsin B levels in CSF: OR for AD per 1 SD of CSF cathepsin B; 0.93, 95% CI; 0.37-2.30, p= 0.87. Plasma cathepsin B levels were higher in persons with AD compared to healthy controls whereas there was no difference between diagnostic groups in cathepsin B levels in CSF. Further investigation of cathepsin B as a predictor of AD is warranted.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sundström, JohanUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)johasund (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
  • Eriksdotter-Jönhagen, MariaKarolinska Institutet (author)
  • Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
  • Larsson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,biologisk struktur och funktion(Swepub:uu)andlarss (author)
  • Degerman-Gunnarsson, MalinUppsala universitet,Geriatrik (author)
  • Ingelsson, MartinUppsala universitet,Geriatrik(Swepub:uu)maing121 (author)
  • Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Kilander, LenaUppsala universitet,Geriatrik(Swepub:uu)lekil226 (author)
  • Basun, HansUppsala universitet,Geriatrik(Swepub:uu)habas169 (author)
  • Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021 (author)
  • Uppsala universitetGeriatrik (creator_code:org_t)

Related titles

  • In:Journal of Alzheimer's Disease22:4, s. 1223-12301387-28771875-8908

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