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Memory T cells effe...
Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant
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- Müller, Thomas R. (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Gao, Yu (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Wu, Jinghua (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Ribeiro, Oriana (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Chen, Puran (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Bergman, Peter (författare)
- Karolinska Institutet,Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Laboratory Medicine, Clinical Immunology, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
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- Blennow, Ola (författare)
- Karolinska Institutet
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- Hansson, Lotta (författare)
- Karolinska Institutet
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- Mielke, Stephan (författare)
- Karolinska Institutet,Department of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden
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- Nowak, Piotr (författare)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
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- Vesterbacka, Jan (författare)
- Karolinska Institutet
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- Akber, Mira (författare)
- Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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- Söderdahl, Gunnar (författare)
- Department of Transplantation, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Smith, C.I. Edvard (författare)
- Karolinska Institutet,Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden
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- Loré, Karin (författare)
- Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Chen, Margaret Sällberg (författare)
- Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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- Ljungman, Per (författare)
- Karolinska Institutet
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- Ingelman-Sundberg, Hanna M. (författare)
- Karolinska Institutet
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- Ljunggren, Hans-Gustaf (författare)
- Karolinska Institutet
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- Österborg, Anders (författare)
- Karolinska Institutet
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- Sette, Alessandro (författare)
- Center for Vaccine Innovation, La Jolla Institute for Immunology (LJI), CA, La Jolla, United States; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), CA, La Jolla, United States
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- Grifoni, Alba (författare)
- Center for Vaccine Innovation, La Jolla Institute for Immunology (LJI), CA, La Jolla, United States
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- Aleman, Soo (författare)
- Karolinska Institutet,Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
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- Buggert, Marcus (författare)
- Karolinska Institutet,Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Cell Host and Microbe. - : Elsevier. - 1931-3128 .- 1934-6069. ; 32:2, s. 156-161.e3
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- T cells are critical in mediating the early control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection. However, it remains unknown whether memory T cells can effectively cross-recognize new SARS-CoV-2 variants with a broad array of mutations, such as the emergent hypermutated BA.2.86 variant. Here, we report in two separate cohorts, including healthy controls and individuals with chronic lymphocytic leukemia, that SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or vaccination demonstrate resilient immune recognition of BA.2.86. In both cohorts, we found largely preserved SARS-CoV-2 spike-specific CD4+ and CD8+ T cell magnitudes against mutated spike epitopes of BA.2.86. Functional analysis confirmed that both cytokine expression and proliferative capacity of SARS-CoV-2 spike-specific T cells to BA.2.86-mutated spike epitopes are similarly sustained. In summary, our findings indicate that memory CD4+ and CD8+ T cells continue to provide cell-mediated immune recognition to highly mutated emerging variants such as BA.2.86.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- BA.1
- BA.2.86
- cellular immunity
- SARS-CoV-2
- T cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Müller, Thomas R ...
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Gao, Yu
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Wu, Jinghua
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Ribeiro, Oriana
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Chen, Puran
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Bergman, Peter
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visa fler...
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Blennow, Ola
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Hansson, Lotta
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Mielke, Stephan
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Nowak, Piotr
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Vesterbacka, Jan
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Akber, Mira
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Söderdahl, Gunna ...
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Smith, C.I. Edva ...
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Loré, Karin
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Chen, Margaret S ...
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Ljungman, Per
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Ingelman-Sundber ...
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Ljunggren, Hans- ...
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Österborg, Ander ...
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Sette, Alessandr ...
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Grifoni, Alba
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Aleman, Soo
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Buggert, Marcus
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Cell Host and Mi ...
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Umeå universitet
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Karolinska Institutet