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Sökning: WFRF:(Roger Sandra) > miR-193b/365a clust...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004143naa a2200565 4500
001oai:DiVA.org:uu-421675
003SwePub
008201012s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:128977855
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4216752 URI
0247 a https://doi.org/10.1093/carcin/bgt4902 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1289778552 URI
040 a (SwePub)uud (SwePub)ki
041 a engb engb -1
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gastaldi, Cécile4 aut
2451 0a miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma.
264 c 2013-12-28
264 1b Oxford University Press (OUP),c 2014
338 a print2 rdacarrier
520 a Incidence of cutaneous squamous cell carcinomas (cSCCs) constantly increases in the Caucasian population. Developing preferentially on precancerous lesions such as actinic keratoses due to chronic sunlight exposure, cSCCs result from the malignant transformation of keratinocytes. Although a resection of the primary tumor is usually curative, a subset of aggressive cSCCs shows a high risk of recurrence and metastases. The characterization of the molecular dysfunctions involved in cSCC development should help to identify new relevant targets against these aggressive cSCCs. In that context, we have used small RNA sequencing to identify 100 microRNAs (miRNAs) whose expression was altered during chemically induced mouse skin tumorigenesis. The decreased expression of the miR-193b/365a cluster during tumor progression suggests a tumor suppressor role. Ectopic expression of these miRNAs in tumor cells indeed inhibited their proliferation, clonogenic potential and migration, which were stimulated in normal keratinocytes when these miRNAs were blocked with antisense oligonucleotides. A combination of in silico predictions and transcriptome analyses identified several target genes of interest. We validated KRAS and MAX as direct targets of miR-193b and miR-365a. Repression of these targets using siRNAs mimicked the effects of miR-193b and miR-365a, suggesting that these genes might mediate, at least in part, the tumor-suppressive action of these miRNAs.
520 a 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Bertero, Thomas4 aut
7001 a Xu, Ningu Karolinska Institutet4 aut
7001 a Bourget-Ponzio, Isabelle4 aut
7001 a Lebrigand, Kévin4 aut
7001 a Fourre, Sandra4 aut
7001 a Popa, Alexandra4 aut
7001 a Cardot-Leccia, Nathalie4 aut
7001 a Meneguzzi, Guerrino4 aut
7001 a Sonkoly, Eniköu Karolinska Institutet4 aut0 (Swepub:uu)enipi547
7001 a Pivarcsi, Andoru Karolinska Institutet4 aut0 (Swepub:uu)andpi932
7001 a Mari, Bernard4 aut
7001 a Barbry, Pascal4 aut
7001 a Ponzio, Gilles4 aut
7001 a Rezzonico, Roger4 aut
7102 a Karolinska Institutet4 org
7730 t Carcinogenesisd : Oxford University Press (OUP)g 35:5, s. 1110-20q 35:5<1110-20x 0143-3334x 1460-2180
8564 u https://academic.oup.com/carcin/article-pdf/35/5/1110/14132933/bgt490.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421675
8564 8u https://doi.org/10.1093/carcin/bgt490
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:128977855

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