AMNE:(Cancer Research.)
Sökning: AMNE:(Cancer Research.) > (2010-2014) > Associations of hor...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06169naa a2200685 4500 | |
| 001 | oai:lup.lub.lu.se:775db729-79f3-45e1-8a1f-a6b482a0ce4a | |
| 003 | SwePub | |
| 008 | 160401s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/45295102 URI |
| 024 | 7 | a https://doi.org/10.1186/1471-2407-14-3712 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Brändstedt, Jennyu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-jyb |
| 245 | 1 0 | a Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability |
| 264 | c 2014-05-25 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2014 |
| 338 | a electronic2 rdacarrier | |
| 520 | a BACKGROUND: Postmenopausal hormone therapy (HRT) and oral contraceptive (OC) use have in several studies been reported to be associated with a decreased colorectal cancer (CRC) risk. However, data on the association between HRT and OC and risk of different clinicopathological and molecular subsets of CRC are lacking. The aim of this molecular pathological epidemiology study was therefore to evaluate the associations between HRT and OC use and risk of specific CRC subgroups, overall and by tumour site.METHOD: In the population-based prospective cohort study Mamö Diet and Cancer, including 17035 women, 304 cases of CRC were diagnosed up until 31 December 2008. Immunohistochemical expression of beta-catenin, cyclin D1, p53 and MSI-screening status had previously been assessed in tissue microarrays with tumours from 280 cases. HRT was assessed as current use of combined HRT (CHRT) or unopposed oestrogen (ERT), and analysed among 12583 peri-and postmenopausal women. OC use was assessed as ever vs never use among all women in the cohort. A multivariate Cox regression model was applied to determine hazard ratios for risk of CRC, overall and according to molecular subgroups, in relation to HRT and OC use.RESULTS: There was no significantly reduced risk of CRC by CHRT or ERT use, however a reduced risk of T-stage 1-2 tumours was seen among CHRT users (HR: 0.24; 95% CI: 0.09-0.77).Analysis stratified by tumour location revealed a reduced overall risk of rectal, but not colon, cancer among CHRT and ERT users, including T stage 1-2, lymph node negative, distant metastasis-free, cyclin D1 - and p53 negative tumours.In unadjusted analysis, OC use was significantly associated with a reduced overall risk of CRC (HR: 0.56; 95% CI: 0.44-0.71), but this significance was not retained in adjusted analysis (HR: 1.05: 95% CI: 0.80-1.37). A similar risk reduction was seen for the majority of clinicopathological and molecular subgroups.CONCLUSION: Our findings provide information on the relationship between use of HRT and OC and risk of clinicopathological and molecular subsets of CRC. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Biomarkers, Tumor | |
| 653 | a Colorectal Neoplasms | |
| 653 | a Contraceptives, Oral, Hormonal | |
| 653 | a Cyclin D1 | |
| 653 | a Estrogen Replacement Therapy | |
| 653 | a Female | |
| 653 | a Genetic Predisposition to Disease | |
| 653 | a Humans | |
| 653 | a Immunohistochemistry | |
| 653 | a Microsatellite Instability | |
| 653 | a Middle Aged | |
| 653 | a Multivariate Analysis | |
| 653 | a Neoplasm Staging | |
| 653 | a Proportional Hazards Models | |
| 653 | a Prospective Studies | |
| 653 | a Risk Assessment | |
| 653 | a Risk Factors | |
| 653 | a Sweden | |
| 653 | a Time Factors | |
| 653 | a Tissue Array Analysis | |
| 653 | a Tumor Suppressor Protein p53 | |
| 653 | a beta Catenin | |
| 653 | a Journal Article | |
| 653 | a Research Support, Non-U.S. Gov't | |
| 700 | 1 | a Wangefjord, Sakariasu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-swa |
| 700 | 1 | a Nodin, Björnu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)immu-bnn |
| 700 | 1 | a Eberhard, Jakobu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-jeb |
| 700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji |
| 700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
| 710 | 2 | a Tumörmikromiljöb Sektion I4 org |
| 773 | 0 | t BMC Cancerd : Springer Science and Business Media LLCg 14:1q 14:1x 1471-2407 |
| 856 | 4 | u https://portal.research.lu.se/files/3270918/5147936x primaryx freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24885829?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1186/1471-2407-14-371x freey FULLTEXT |
| 856 | 4 | u https://bmccancer.biomedcentral.com/track/pdf/10.1186/1471-2407-14-371 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4529510 |
| 856 | 4 8 | u https://doi.org/10.1186/1471-2407-14-371 |
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