Sökning: L773:0163 2116 OR L773:1573 2568 >
The effect of opioi...
The effect of opioids on the development of postoperative intra-abdominal adhesions.
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- Khorram-Manesh, Amir, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Ardakani, Jalal Vahedian (författare)
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Behjati, Hamid Reza (författare)
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- Nylund, Gunnar, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Delbro, Dick, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2006
- 2006
- Engelska.
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Ingår i: Digestive diseases and sciences. - : Springer Science and Business Media LLC. - 0163-2116 .- 1573-2568. ; 51:3, s. 560-5
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- People addicted to opium rarely develop intra-abdominal adhesions after abdominal surgery. We aimed to evaluate the effect of opium or morphine on preventing postoperative adhesions in rats. Sixty-three rats were randomly divided into a control group, opium-addicted group, and morphine-addicted group in a double-blind study. Drug dependency was checked by using naloxone. Animals were then operated on and the cecum was abraded. At reoperation 3 weeks later the magnitude of adhesions was evaluated by a scoring system. There was a significant difference between the control, opium-addicted, and morphine-addicted groups with regard to the length (P < .001), thickness (P < .05), and severity of adhesions (P < .05). Opium or morphine reduces the severity of postoperative adhesions. Elucidation of the opioid receptor(s) involved in this process would enable the use of selective ligands and offer a pharmacologic strategy in preventing adhesion formation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Adhesions
- prevention & control
- Animals
- Cecum
- drug effects
- pathology
- Disease Models
- Animal
- Female
- Laparotomy
- adverse effects
- Morphine
- pharmacology
- Narcotics
- pharmacology
- Opium
- pharmacology
- Postoperative Complications
- prevention & control
- Random Allocation
- Rats
- Rats
- Inbred Strains
- Reference Values
- Risk Factors
- Sensitivity and Specificity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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