Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis

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Jonefjäll, BörjeGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Department of Internal Medicine, Kungälv Hospital, Kungälv, Sweden (författare)

Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis

Artikel/kapitelEngelska2018

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2017-04-03
Wiley,2018

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LIBRIS-ID:oai:gup.ub.gu.se/264140
https://gup.ub.gu.se/publication/264140URI
https://doi.org/10.1177/2050640617703868DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14708URI

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Språk:engelska

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Background: Patients with ulcerative colitis often report fatigue. Objectives: To investigate prevalence of and risk factors for fatigue in patients with ulcerative colitis with active disease and during deep remission. Methods: In this cross-sectional study, disease activity was evaluated with endoscopy and calprotectin, and patients were classified as having active disease (n=133) or being in deep remission (n=155). Blood samples were analysed to assess anaemia, iron deficiency and systemic immune activity. Patients completed questionnaires to assess fatigue, psychological distress, gastrointestinal symptoms and quality of life. Results: The prevalence of high fatigue (general fatigue >= 13, Multidimensional Fatigue Inventory) was 40% in the full study population. Among patients with high fatigue, female gender and iron deficiency were more prevalent, and these patients had more severe disease activity and reported higher levels of anxiety, depression and decreased quality of life compared with patients with no/mild fatigue. A logistic regression analysis identified probable psychiatric disorder (odds ratio (OR) (confidence interval) 6.1 (3.1-12.2)), iron deficiency (OR 2.5 (1.2-5.1)), active disease (OR 2.2 (1.2-3.9)) and female gender (OR 2.1 (1.1-3.7)) as independent risk factors for high fatigue. Similar results were found concerning psychological distress, gender and quality of life, but immune markers did not differ in patients in deep remission with high vs. no/mild fatigue. Conclusions: Probable psychiatric disorder, iron deficiency, active disease and female gender are independent risk factors for high fatigue in patients with ulcerative colitis. Low-grade immune activity does not seem to be the cause of fatigue among patients in deep remission.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Ulcerative colitis
inflammatory bowel disease
fatigue
psychiatric disease
iron deficiency
inflammatory-bowel-disease
quality-of-life
ibs-like symptoms
gastrointestinal symptoms
depression scale
hospital anxiety
remission
prevalence
management
disorders
Gastroenterology & Hepatology
Ulcerative colitis
Translationell medicin TRIM

Biuppslag (personer, institutioner, konferenser, titlar ...)

Simrén, Magnus,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC, USA(Swepub:gu)xsimrm (författare)
Lasson, A.Department of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden / Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg (författare)
Öhman, Lena,1967Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Department of Microbiology and Immunology, Gothenburg, Sweden,Translationell medicin (TRIM), Translational Medicine(Swepub:his)ohml (författare)
Strid, Hans,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Department of Internal Medicine, Södra Älvsborgs Hospital, Bora ̊ s, Sweden 5 Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg(Swepub:gu)xstrha (författare)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (creator_code:org_t)

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Ingår i:United European Gastroenterology Journal: Wiley6:1, s. 148-1582050-64062050-6414

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Av författaren/redakt...: Jonefjäll, Börje; Simrén, Magnus, ...; Lasson, A.; Öhman, Lena, 196 ...; Strid, Hans, 195 ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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