Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis

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Fältnamn	Indikatorer	Metadata
000		06528naa a2200613 4500
001		oai:gup.ub.gu.se/264140
003		SwePub
008		240528s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:his-14708
024	7	a https://gup.ub.gu.se/publication/2641402 URI
024	7	a https://doi.org/10.1177/20506406177038682 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-147082 URI
040		a (SwePub)gud (SwePub)his
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Jonefjäll, Börjeu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Department of Internal Medicine, Kungälv Hospital, Kungälv, Sweden4 aut
245	1 0	a Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis
264		c 2017-04-03
264	1	b Wiley,c 2018
520		a Background: Patients with ulcerative colitis often report fatigue. Objectives: To investigate prevalence of and risk factors for fatigue in patients with ulcerative colitis with active disease and during deep remission. Methods: In this cross-sectional study, disease activity was evaluated with endoscopy and calprotectin, and patients were classified as having active disease (n=133) or being in deep remission (n=155). Blood samples were analysed to assess anaemia, iron deficiency and systemic immune activity. Patients completed questionnaires to assess fatigue, psychological distress, gastrointestinal symptoms and quality of life. Results: The prevalence of high fatigue (general fatigue >= 13, Multidimensional Fatigue Inventory) was 40% in the full study population. Among patients with high fatigue, female gender and iron deficiency were more prevalent, and these patients had more severe disease activity and reported higher levels of anxiety, depression and decreased quality of life compared with patients with no/mild fatigue. A logistic regression analysis identified probable psychiatric disorder (odds ratio (OR) (confidence interval) 6.1 (3.1-12.2)), iron deficiency (OR 2.5 (1.2-5.1)), active disease (OR 2.2 (1.2-3.9)) and female gender (OR 2.1 (1.1-3.7)) as independent risk factors for high fatigue. Similar results were found concerning psychological distress, gender and quality of life, but immune markers did not differ in patients in deep remission with high vs. no/mild fatigue. Conclusions: Probable psychiatric disorder, iron deficiency, active disease and female gender are independent risk factors for high fatigue in patients with ulcerative colitis. Low-grade immune activity does not seem to be the cause of fatigue among patients in deep remission.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653		a Ulcerative colitis
653		a inflammatory bowel disease
653		a fatigue
653		a psychiatric disease
653		a iron deficiency
653		a inflammatory-bowel-disease
653		a quality-of-life
653		a ibs-like symptoms
653		a gastrointestinal symptoms
653		a depression scale
653		a hospital anxiety
653		a remission
653		a prevalence
653		a management
653		a disorders
653		a Gastroenterology & Hepatology
653		a Ulcerative colitis
653		a Translationell medicin TRIM
700	1	a Simrén, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC, USA4 aut0 (Swepub:gu)xsimrm
700	1	a Lasson, A.u Department of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden / Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg4 aut
700	1	a Öhman, Lena,d 1967u Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Department of Microbiology and Immunology, Gothenburg, Sweden,Translationell medicin (TRIM), Translational Medicine4 aut0 (Swepub:his)ohml
700	1	a Strid, Hans,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden / Department of Internal Medicine, Södra Älvsborgs Hospital, Bora ̊ s, Sweden 5 Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg4 aut0 (Swepub:gu)xstrha
710	2	a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org
773	0	t United European Gastroenterology Journald : Wileyg 6:1, s. 148-158q 6:1<148-158x 2050-6406x 2050-6414
856	4	u https://journals.sagepub.com/doi/pdf/10.1177/2050640617703868
856	4 8	u https://gup.ub.gu.se/publication/264140
856	4 8	u https://doi.org/10.1177/2050640617703868
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14708

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Av författaren/redakt...: Jonefjäll, Börje; Simrén, Magnus, ...; Lasson, A.; Öhman, Lena, 196 ...; Strid, Hans, 195 ...

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