Obesity, metabolic factors and risk of different histological types of lung cancer: a Mendelian randomization study

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Fältnamn	Indikatorer	Metadata
000		09578naa a2201129 4500
001		oai:DiVA.org:umu-137383
003		SwePub
008		170706s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:c57d2208-8a7c-4b90-a329-db261e03f196
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1373832 URI
024	7	a https://doi.org/10.1371/journal.pone.01778752 DOI
024	7	a https://lup.lub.lu.se/record/c57d2208-8a7c-4b90-a329-db261e03f1962 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Carreras-Torres, Robertu International Agency for Research on Cancer, World Health Organization4 aut
245	1 0	a Obesity, metabolic factors and risk of different histological types of lung cancer :b a Mendelian randomization study
264		c 2017-06-08
264	1	b Public library science,c 2017
338		a electronic2 rdacarrier
520		a Background: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. Methods and findings: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01-1.43] and for small cell lung cancer (OR [95% CI] = 1.52 [1.15-2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m(2)]), but not for adenocarcinoma (OR [95% CI] = 0.93 [0.79-1.08]) (P-heterogeneity = 4.3x10(-3)). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10(-3)), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95% CI] = 0.90 [0.84-0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95% CI] = 1.63 [1.25-2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results. Conclusions: Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Johansson, Mattiasu International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Haycock, Philip C.u University of Bristol,Fred Hutchinson Cancer Research Center4 aut
700	1	a Wade, Kaitlin H.u University of Bristol4 aut
700	1	a Relton, Caroline L.u University of Bristol4 aut
700	1	a Martin, Richard M.u University of Bristol4 aut
700	1	a Smith, George Daveyu University of Bristol4 aut
700	1	a Albanes, Demetriusu National Cancer Institute, USA4 aut
700	1	a Aldrich, Melinda C.u Vanderbilt University4 aut
700	1	a Andrew, Angelineu Norris Cotton Cancer Center,Dartmouth College,University of Liverpool,Radboud University Medical Center4 aut
700	1	a Arnold, Susanne M.u University of Kentucky4 aut
700	1	a Bickeböller, Heikeu University of Göttingen4 aut
700	1	a Bojesen, Stig E.u University of Copenhagen4 aut
700	1	a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)med-hsb
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)smi-jma
700	1	a Brüske, Ireneu Helmholtz Zentrum München4 aut
700	1	a Caporaso, Neil E.u National Cancer Institute, NCI4 aut
700	1	a Chen, Chuu Harvard T.H. Chan School of Public Health,Harvard Medical School4 aut
700	1	a Christiani, David C.4 aut
700	1	a Christian, W. Jayu University of Kentucky4 aut
700	1	a Doherty, Jennifer A.4 aut
700	1	a Duell, Eric J.u Catalan Institute of Oncology4 aut
700	1	a Field, John K.u University of Liverpool4 aut
700	1	a Davies, Michael P. A.4 aut
700	1	a Marcus, Michael W.u University of Liverpool4 aut
700	1	a Goodman, Gary E.u Fred Hutchinson Cancer Research Center4 aut
700	1	a Grankvist, Kjellu Umeå University,Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
700	1	a Haugen, Aageu National Institute of Occupational Health, Norway4 aut
700	1	a Hong, Yun-Chulu Seoul National University4 aut
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a van der Heijden, Erik H. F. M.u Radboud University Medical Center4 aut
700	1	a Kraft, Peteru Harvard T.H. Chan School of Public Health4 aut
700	1	a Johansson, Mikael B.u Umeå University,Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
700	1	a Lam, Stephenu British Columbia Cancer Agency4 aut
700	1	a Landi, Maria Teresau National Cancer Institute, USA4 aut
700	1	a Lazarus, Philipu Washington State University College of Pharmacy4 aut
700	1	a Le Marchand, Loïcu University of Hawaii Cancer Center4 aut
700	1	a Liu, Geoffreyu Princess Margaret Hospital University of Toronto4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome
700	1	a Park, Sungshim L.u University of Southern California4 aut
700	1	a Rennert, Gadu Technion - Israel Institute of Technology4 aut
700	1	a Risch, Angelau University of Salzburg4 aut
700	1	a Haura, Eric B.u H. Lee Moffitt Cancer Center & Research Institute4 aut
700	1	a Scelo, Ghislaineu International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Zaridze, Davidu N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences4 aut
700	1	a Mukeriya, Anushu N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences4 aut
700	1	a Savić, Milanu Clinical Center of Serbia4 aut
700	1	a Lissowska, Jolantau The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology4 aut
700	1	a Swiatkowska, Beatau Nofer Institute of Occupational Medicine4 aut
700	1	a Janout, Vladimiru University of Ostrava4 aut
700	1	a Holcatova, Ivanau Charles University in Prague4 aut
700	1	a Mates, Danau National Institute of Public Health, Romania4 aut
700	1	a Schabath, Matthew B.u H. Lee Moffitt Cancer Center & Research Institute4 aut
700	1	a Shen, Hongbingu Nanjing Medical University4 aut
700	1	a Tardon, Adoninau University of Oviedo4 aut
700	1	a Teare, Dawnu University of Sheffield4 aut
700	1	a Woll, Penellau University of Sheffield4 aut
700	1	a Tsao, Ming-Soundu Princess Margaret Hospital University of Toronto4 aut
700	1	a Wu, Xifengu University of Texas4 aut
700	1	a Yuan, Jian-Minu University of Pittsburgh Cancer Institute4 aut
700	1	a Hung, Rayjean J.u Mount Sinai Hospital of University of Toronto4 aut
700	1	a Amos, Christopher I.u Dartmouth College4 aut
700	1	a McKay, Jamesu International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Brennan, Paulu International Agency for Research on Cancer, World Health Organization4 aut
710	2	a International Agency for Research on Cancer, World Health Organizationb University of Bristol4 org
773	0	t PLOS ONEd : Public library scienceg 12:6q 12:6x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0177875y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1120595/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0177875&type=printable
856	4	u http://dx.doi.org/10.1371/journal.pone.0177875x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137383
856	4 8	u https://doi.org/10.1371/journal.pone.0177875
856	4 8	u https://lup.lub.lu.se/record/c57d2208-8a7c-4b90-a329-db261e03f196

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Av författaren/redakt...: Carreras-Torres, ...; Johansson, Matti ...; Haycock, Philip ...; Wade, Kaitlin H.; Relton, Caroline ...; Martin, Richard ...; visa fler...; Smith, George Da ...; Albanes, Demetri ...; Aldrich, Melinda ...; Andrew, Angeline; Arnold, Susanne ...; Bickeböller, Hei ...; Bojesen, Stig E.; Brunnström, Hans; Manjer, Jonas; Brüske, Irene; Caporaso, Neil E ...; Chen, Chu; Christiani, Davi ...; Christian, W. Ja ...; Doherty, Jennife ...; Duell, Eric J.; Field, John K.; Davies, Michael ...; Marcus, Michael ...; Goodman, Gary E.; Grankvist, Kjell; Haugen, Aage; Hong, Yun-Chul; Kiemeney, Lamber ...; van der Heijden, ...; Kraft, Peter; Johansson, Mikae ...; Lam, Stephen; Landi, Maria Ter ...; Lazarus, Philip; Le Marchand, Loï ...; Liu, Geoffrey; Melander, Olle; Park, Sungshim L ...; Rennert, Gad; Risch, Angela; Haura, Eric B.; Scelo, Ghislaine; Zaridze, David; Mukeriya, Anush; Savić, Milan; Lissowska, Jolan ...; Swiatkowska, Bea ...; Janout, Vladimir; Holcatova, Ivana; Mates, Dana; Schabath, Matthe ...; Shen, Hongbing; Tardon, Adonina; Teare, Dawn; Woll, Penella; Tsao, Ming-Sound; Wu, Xifeng; Yuan, Jian-Min; Hung, Rayjean J.; Amos, Christophe ...; McKay, James; Brennan, Paul; visa färre...

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