SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Gabriella C. M.)
 

Search: WFRF:(Gabriella C. M.) > The IGFBP3/TMEM219 ...

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

DAddio, Francesca (author)
Univ Milan, Italy
Maestroni, Anna (author)
Univ Milan, Italy
Assi, Emma (author)
Univ Milan, Italy
show more...
Ben Nasr, Moufida (author)
Univ Milan, Italy; Harvard Med Sch, MA 02115 USA; Harvard Med Sch, MA 02115 USA
Amabile, Giovanni (author)
Enthera Srl, Italy
Usuelli, Vera (author)
Univ Milan, Italy; Harvard Med Sch, MA 02115 USA; Harvard Med Sch, MA 02115 USA
Loretelli, Cristian (author)
Univ Milan, Italy
Bertuzzi, Federico (author)
ASST Grande Osped Metropolitano Niguarda, Italy
Antonioli, Barbara (author)
ASST Grande Osped Metropolitano Niguarda, Italy
Cardarelli, Francesco (author)
NEST Scuola Normale Super, Italy
El Essawy, Basset (author)
Brigham & Womens Hosp, MA 02115 USA; Al Azhar Univ, Egypt
Solini, Anna (author)
Univ Pisa, Italy
Gerling, Ivan C. (author)
Univ Tennessee, TN 38104 USA
Bianchi, Cristina (author)
Univ Pisa, Italy; Azienda Osped Univ Pisana, Italy
Becchi, Gabriella (author)
Univ Parma, Italy
Mazzucchelli, Serena (author)
Univ Milan, Italy
Corradi, Domenico (author)
Univ Parma, Italy
Fadini, Gian Paolo (author)
Univ Padua, Italy
Foschi, Diego (author)
Univ Milan, Italy
Markmann, James F. (author)
Harvard Med Sch, MA 02115 USA
Orsi, Emanuela (author)
IRCCS Ca Granda Osped Maggiore Policlin Fdn, Italy
Skrha, Jan (author)
Charles Univ Prague, Czech Republic
Camboni, Maria Gabriella (author)
Enthera Srl, Italy
Abdi, Reza (author)
Brigham & Womens Hosp, MA 02115 USA
Shapiro, A. M. James (author)
Univ Alberta, Canada
Folli, Franco (author)
Univ Milan, Italy
Ludvigsson, Johnny (author)
Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
Del Prato, Stefano (author)
Univ Pisa, Italy; Azienda Osped Univ Pisana, Italy
Zuccotti, Gianvincenzo (author)
Univ Milan, Italy; Buzzi Childrens Hosp, Italy
Fiorina, Paolo (author)
Univ Milan, Italy; Harvard Med Sch, MA 02115 USA; Harvard Med Sch, MA 02115 USA; ASST Fatebenefratelli Sacco, Italy
show less...
 (creator_code:org_t)
2022-02-03
2022
English.
In: Nature Communications. - : Nature Portfolio. - 2041-1723. ; 13:1
Related links:
https://liu.diva-por... (primary) (Raw object)
show more...
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes. Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death receptor TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. Increased peripheral IGFBP3 was observed in established and at-risk T1D/T2D patients and was confirmed in T1D/T2D preclinical models, suggesting that dysfunctional IGFBP3/TMEM219 signaling is associated with abnormalities in beta cells homeostasis. In vitro and in vivo short-term IGFBP3/TMEM219 inhibition and TMEM219 genetic ablation preserved beta cells and prevented/delayed diabetes onset, while long-term IGFBP3/TMEM219 blockade allowed for beta cell expansion. Interestingly, in several patients cohorts restoration of appropriate IGFBP3 levels was associated with improved beta cell function. The IGFBP3/TMEM219 pathway is thus shown to be a physiological regulator of beta cell homeostasis and is also demonstrated to be disrupted in T1D/T2D. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view