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Effects of 6 weeks ...
Effects of 6 weeks of treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, on myocardial function and metabolism in patients with type 2 diabetes : A randomized, placebo-controlled, exploratory study
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- Oldgren, Jonas, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Laurila, Sanna (författare)
- Turku Univ Hosp, Ctr Heart, Turku, Finland.;Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku, Finland.;Satakunta Cent Hosp, Pori, Finland.
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- Åkerblom, Axel, 1977- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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- Latva-Rasku, Aino (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku, Finland.
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- Rebelos, Eleni (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku, Finland.
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- Isackson, Henrik (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
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- Saarenhovi, Maria (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku, Finland.
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- Eriksson, Olof (författare)
- Antaros Med AB, Mölndal, Sweden.
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- Heurling, Kerstin (författare)
- Antaros Med AB, Mölndal, Sweden.
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- Johansson, Edvin (författare)
- Antaros Med AB, Mölndal, Sweden.
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- Wilderang, Ulrica (författare)
- AstraZeneca, BioPharmaceut R&D, Gothenburg, Sweden.
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- Karlsson, Cecilia (författare)
- AstraZeneca, BioPharmaceut R&D, Gothenburg, Sweden.
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- Esterline, Russell (författare)
- AstraZeneca, BioPharmaceut R&D, Gaithersburg, MD USA.
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- Ferrannini, Ele (författare)
- CNR, Inst Clin Physiol, Pisa, Italy.
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- Oscarsson, Jan (författare)
- AstraZeneca, BioPharmaceut R&D, Gothenburg, Sweden.
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- Nuutila, Pirjo (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland.;Turku Univ Hosp, Turku, Finland.
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(creator_code:org_t)
- 2021-03-12
- 2021
- Engelska.
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Ingår i: Diabetes, obesity and metabolism. - : John Wiley & Sons. - 1462-8902 .- 1463-1326. ; 23:7, s. 1505-1517
- Relaterad länk:
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https://doi.org/10.1...
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aim To explore the early effects of dapagliflozin on myocardial function and metabolism in patients with type 2 diabetes without heart failure. Materials and Methods Patients with type 2 diabetes on metformin treatment were randomized to double-blind, 6-week placebo or dapagliflozin 10 mg daily treatment. Investigations included cardiac function and structure with myocardial resonance imaging; cardiac oxygen consumption, perfusion and efficiency with [C-11]-acetate positron emission tomography (PET); and cardiac and hepatic fatty acid uptake with [F-18]-6-thia-heptadecanoic acid PET, analysed by ANCOVA as least square means with 95% confidence intervals. Results Evaluable patients (placebo: n = 24, dapagliflozin: n = 25; 53% males) had a mean age of 64.4 years, a body mass index of 30.2 kg/m(2) and an HbA1c of 6.7%. Body weight and HbA1c were significantly decreased by dapagliflozin versus placebo. Dapagliflozin had no effect on myocardial efficiency, but external left ventricular (LV) work (-0.095 [-0.145, -0.043] J/g/min) and LV oxygen consumption were significantly reduced (-0.30 [-0.49, -0.12] J/g/min) by dapagliflozin, although the changes were not statistically significant versus changes in the placebo group. Change in left atrial maximal volume with dapagliflozin versus placebo was -3.19 (-6.32, -0.07) mL/m(2) (p = .056). Peak global radial strain decreased with dapagliflozin versus placebo (-3.92% [-7.57%, -0.28%]; p = .035), while peak global longitudinal and circumferential strains were unchanged. Hepatic fatty acid uptake was increased by dapagliflozin versus placebo (0.024 [0.004, 0.044] mu mol/g/min; p = .018), while cardiac uptake was unchanged. Conclusions This exploratory study indicates reduced heart work but limited effects on myocardial function, efficiency and cardiac fatty acid uptake, while hepatic fatty acid uptake increased, after 6 weeks of treatment with dapagliflozin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- dapagliflozin
- SGLT2 inhibitor
- type 2 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Oldgren, Jonas, ...
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Laurila, Sanna
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Åkerblom, Axel, ...
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Latva-Rasku, Ain ...
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Rebelos, Eleni
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Isackson, Henrik
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Saarenhovi, Mari ...
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Eriksson, Olof
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Heurling, Kersti ...
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Johansson, Edvin
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Wilderang, Ulric ...
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Karlsson, Cecili ...
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Esterline, Russe ...
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Ferrannini, Ele
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Oscarsson, Jan
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Nuutila, Pirjo
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